交沙霉素对需氧革兰氏阳性球菌和厌氧菌的体外活性。
In vitro activity of josamycin against aerobic gram-positive cocci and anaerobes.
作者信息
Westerman E L, Williams T W, Moreland N
出版信息
Antimicrob Agents Chemother. 1976 Jun;9(6):988-93. doi: 10.1128/AAC.9.6.988.
Josamycin, a new macrolide antibiotic, was compared with ampicillin, erythromycin, and clindamycin in vitro against 25 isolates each of pneumococci, enterococci, Staphylococcus aureus, S. epidermidis, and nonenterococcal hemolytic streptococci and against 25 anaerobes including 10 Bacteroides fragilis. Minimal inhibitory concentration and minimal bactericidal concentration data were obtained for the aerobic organisms, using serial twofold tube dilutions in Mueller-Hinton broth. Minimal inhibitory concentrations were determined for the anaerobes by the agar dilution technique. Josamycin was comparable to erythromycin and clindamycin in activity against the pneumococci, streptococci, and staphylococci and was more active than clindamycin against enterococci. It was somewhat less active than ampicillin against enterococci and S. epidermidis and showed its greatest in vitro activity against anaerobes, being comparable to clindamycin.
新型大环内酯类抗生素交沙霉素在体外与氨苄西林、红霉素和克林霉素进行比较，测试对象包括25株肺炎球菌、肠球菌、金黄色葡萄球菌、表皮葡萄球菌和非肠球菌性溶血性链球菌，以及25株厌氧菌，其中包括10株脆弱拟杆菌。采用在Mueller-Hinton肉汤中进行系列两倍稀释的方法，获取需氧菌的最低抑菌浓度和最低杀菌浓度数据。通过琼脂稀释技术测定厌氧菌的最低抑菌浓度。交沙霉素在抗肺炎球菌、链球菌和葡萄球菌的活性方面与红霉素和克林霉素相当，在抗肠球菌方面比克林霉素更具活性。在抗肠球菌和表皮葡萄球菌方面，其活性略低于氨苄西林，在体外对厌氧菌的活性最强，与克林霉素相当。
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