艾滋病患者多形核白细胞的抗念珠菌活性以及白细胞介素-1β和白细胞介素-6的产生得以保留。
Anticandidal activity and interleukin-1 beta and interleukin-6 production by polymorphonuclear leukocytes are preserved in subjects with AIDS.
作者信息
Cassone A, Palma C, Djeu J Y, Aiuti F, Quinti I
机构信息
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy.
出版信息
J Clin Microbiol. 1993 May;31(5):1354-7. doi: 10.1128/jcm.31.5.1354-1357.1993.
Abstract
Polymorphonuclear granulocytes (PMN; or neutrophils) from uninfected or human immunodeficiency virus-infected subjects were tested for their ability to inhibit growth of Candida albicans and produce interleukin-1 beta (IL-1 beta) and IL-6 in vitro. It was seen that PMN from AIDS (Centers for Disease Control stage IV) patients expressed equal if not greater anticandidal activity compared with the activity expressed by neutrophils from all other subjects examined. On exposure to granulocyte macrophage-colony-stimulating factor or to a mannoprotein constituent (MP-F2) from C. albicans itself, PMN from AIDS patients showed enhanced antifungal activity and production of remarkable quantities of IL-1 beta and IL-6. These findings suggest that the functional abilities of PMN to inhibit Candida growth and secrete relevant proinflammatory and immunomodulatory cytokines are intrinsically preserved in AIDS patients.
摘要
对来自未感染或感染人类免疫缺陷病毒的受试者的多形核粒细胞（PMN；即中性粒细胞）进行体外测试，以检测其抑制白色念珠菌生长以及产生白细胞介素-1β（IL-1β）和IL-6的能力。结果发现，与所有其他受试对象的中性粒细胞相比，艾滋病（疾病控制中心IV期）患者的PMN表现出同等甚至更强的抗念珠菌活性。暴露于粒细胞巨噬细胞集落刺激因子或白色念珠菌自身的一种甘露糖蛋白成分（MP-F2）后，艾滋病患者的PMN表现出增强的抗真菌活性，并产生大量的IL-1β和IL-6。这些发现表明，艾滋病患者PMN抑制念珠菌生长以及分泌相关促炎和免疫调节细胞因子的功能能力在本质上得以保留。
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