Pascoe P J, Dyson D H
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
Vet Surg. 1993 Mar-Apr;22(2):141-7. doi: 10.1111/j.1532-950x.1993.tb01689.x.
One of two analgesic treatments was randomly assigned to 40 dogs undergoing lateral thoracotomy. Group E (20 dogs) received an epidural injection of morphine (0.1 mg/kg) before surgery. Group I (20 dogs) received injections of bupivacaine around five intercostal nerves when the thorax was about to be closed. All dogs were given an opioid as part of their preoperative medication (meperidine or butorphanol), followed by thiopental for induction and halothane or methoxyflurane for maintenance of anesthesia. Scores were assigned for pre-operative demeanor and response to restraint and injection. Alertness, undisturbed pain behavior, and response to palpation of the wound were assessed 3, 6, 12, and 24 hours after surgery. Dogs that appeared uncomfortable were given analgesics. Blood for evaluation of arterial blood gases was obtained at 3 and 6 hours after surgery. The person scoring the dogs was blinded to the treatment given. There were no statistically significant differences between the groups. Group E contained more "nervous" dogs (12 vs. 6) and more dogs in group E received postoperative analgesics (8 vs. 2). Both techniques appeared to provide adequate analgesia for most dogs.
两种镇痛治疗方法之一被随机分配给40只接受侧胸切开术的犬。E组(20只犬)在手术前接受硬膜外注射吗啡(0.1mg/kg)。I组(20只犬)在胸腔即将关闭时在五条肋间神经周围注射布比卡因。所有犬术前均给予阿片类药物作为术前用药的一部分(哌替啶或布托啡诺),随后用硫喷妥钠诱导麻醉,并用氟烷或甲氧氟烷维持麻醉。对术前的行为表现以及对约束和注射的反应进行评分。在术后3、6、12和24小时评估警觉性、安静时的疼痛行为以及对伤口触诊的反应。表现出不适的犬给予镇痛药。在术后3和6小时采集血液用于评估动脉血气。给犬评分的人员对所给予的治疗不知情。两组之间无统计学显著差异。E组有更多“紧张”的犬(12只对6只),且E组有更多犬接受了术后镇痛药(8只对2只)。两种技术似乎都能为大多数犬提供充分的镇痛效果。