Schäffler L, Lüders H O, Dinner D S, Lesser R P, Chelune G J
Cleveland Clinic Epilepsy Program, Department of Neurology, OH 44195.
Brain. 1993 Jun;116 ( Pt 3):695-715. doi: 10.1093/brain/116.3.695.
We report on three patients with intractable focal seizures arising from the language-dominant left hemisphere. In the work-up prior to surgical treatment, arrays of subdural electrodes were placed over the left temporal lobe and adjacent supra-Sylvian region. Electrical stimulation of the inferior frontal cortex language region ('Broca's area') produced marked interference with language output functions including speech arrest, slowing of oral reading, paraphasia and anomia. At some cortical language sites in this region cortical stimulation also produced language comprehension deficits, particularly in response to more complex auditory verbal instructions and visual semantic material. The severe impairment of comprehension verbal information was in clear contrast with ability to process non-verbal material, which was not affected.
我们报告了3例源于左侧语言优势半球的顽固性局灶性癫痫患者。在手术治疗前的检查过程中，将硬膜下电极阵列放置在左侧颞叶和相邻的颞上区域。对额下皮质语言区（“布罗卡区”）进行电刺激会对语言输出功能产生明显干扰，包括言语停顿、朗读速度减慢、言语错乱和命名障碍。在该区域的一些皮质语言部位，皮质刺激还会导致语言理解缺陷，尤其是在对更复杂的听觉语言指令和视觉语义材料做出反应时。言语信息理解的严重受损与处理不受影响的非言语材料的能力形成鲜明对比。
