Otieno M R, McLigeyo S O, Kigondu C S, Rogo K O
Aga Khan Hospital, Nairobi.
East Afr Med J. 1993 Jan;70(1):6-9.
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
40名年龄在14至35岁（平均28.6岁）的慢性肾衰竭（CRF）女性被纳入该研究。记录她们的月经模式。对于月经仍正常的患者（第一组），在月经周期的不同阶段通过血清卵泡刺激素（FSH）、黄体生成素（LH）、催乳素（PrL）、雌二醇（E2）和孕酮（P）水平评估其下丘脑 - 垂体 - 卵巢轴功能；对于月经紊乱的患者（第二组），则在六周内每周进行一次评估。第一组患者初始黄体期的平均激素水平为：FSH 12.0 IU/L（正常范围1.0 - 3.0 IU/L）、LH 1.8IU/L（正常范围1.5 - 10IU/L）、PrL 652mIU/L（正常范围100 - 600 mIU/L）、E2 160 pmol/L（正常范围400 - 1400 pmol/L）和P5 nmol/L（正常范围14 - 60 nmol/L）。第二组的相应值分别为1.2、10.3、250、600和3.0（单位相关）。所有终末期肾病（ESRD）患者（14名）均闭经。另一方面，大多数稳定的CRF患者（22/26）月经正常。开始治疗（保守治疗或透析）后，激素水平或月经模式无明显变化。我们得出结论，除激素失衡外，其他因素可能是CRF患者出现月经紊乱的原因。
