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In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth.头孢噻肟、环丙沙星和庆大霉素多次暴露于合并的人脑脊液和穆勒-欣顿肉汤中对大肠杆菌产生的体外抗生素后效应。
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Cerebrospinal fluid proteins in neurology.
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Postantibiotic effect of roxithromycin, erythromycin, and clindamycin against selected gram-positive bacteria and Haemophilus influenzae.罗红霉素、红霉素和克林霉素对所选革兰氏阳性菌及流感嗜血杆菌的抗生素后效应
J Antimicrob Chemother. 1987 Nov;20 Suppl B:39-46. doi: 10.1093/jac/20.suppl_b.39.
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Killing and regrowth of bacteria in vitro: a review.
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The postantibiotic effect: a review of in vitro and in vivo data.抗生素后效应：体外和体内数据综述
DICP. 1991 Feb;25(2):153-63. doi: 10.1177/106002809102500210.
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Ionic binding, adaptive resistance and post-antibiotic effect of netilmicin and ciprofloxacin.
J Antimicrob Chemother. 1991 Jun;27(6):741-8. doi: 10.1093/jac/27.6.741.
6
Human serum enhances the postantibiotic effect of fluoroquinolones against Staphylococcus aureus.人血清增强氟喹诺酮类药物对金黄色葡萄球菌的抗生素后效应。
Antimicrob Agents Chemother. 1991 Jun;35(6):1261-3. doi: 10.1128/AAC.35.6.1261.
7
Influence of human urine on the in vitro activity and postantibiotic effect of ciprofloxacin against Escherichia coli.人尿对环丙沙星体外抗大肠杆菌活性及抗生素后效应的影响。
Chemotherapy. 1991;37(3):218-23. doi: 10.1159/000238857.
8
Effect of pooled human cerebrospinal fluid on the postantibiotic effects of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli.混合人脑脊液对头孢噻肟、环丙沙星和庆大霉素针对大肠杆菌的抗生素后效应的影响。
Antimicrob Agents Chemother. 1992 May;36(5):1136-9. doi: 10.1128/AAC.36.5.1136.
9
Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time.抗生素在短时间暴露后对金黄色葡萄球菌的持续影响。
J Infect Dis. 1977 Feb;135(2):217-23. doi: 10.1093/infdis/135.2.217.
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Classification of cells in the cerebrospinal fluid. A review.脑脊液中细胞的分类。综述
Eur Neurol. 1977;15(3):169-76. doi: 10.1159/000114808.

头孢噻肟、环丙沙星和庆大霉素多次暴露于合并的人脑脊液和穆勒-欣顿肉汤中对大肠杆菌产生的体外抗生素后效应。

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth.

作者信息

Karlowsky J A, Zhanel G G, Davidson R J, Zieroth S R, Hoban D J

机构信息

Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.

出版信息

Antimicrob Agents Chemother. 1993 May;37(5):1154-7. doi: 10.1128/AAC.37.5.1154.

DOI:10.1128/AAC.37.5.1154
PMID:8517705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187920/
Abstract

Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.

摘要

在穆勒-欣顿肉汤或脑脊液中多次使用头孢噻肟对所测试的大肠杆菌菌株的杀菌效果或抗生素后效应（PAE）持续时间均无影响。然而，在穆勒-欣顿肉汤中多次使用后，环丙沙星和庆大霉素的PAE显著降低，同时细菌杀灭率也随之下降。在脑脊液中多次使用环丙沙星和庆大霉素后，细菌杀灭率也出现下降；不过，PAE得以维持。