Wahlberg G, Walldius G
King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden.
Int J Clin Lab Res. 1993;23(2):88-94. doi: 10.1007/BF02592289.
Thirty-one weight-stable patients with different types of hyperlipoproteinemia were treated daily with 4 g nicotinic acid for 6 weeks. Effects of this therapy on adipose tissue metabolism were evaluated. By using biopsy specimens of subcutaneous adipose tissue, fatty acid and glucose incorporation into adipose tissue glycerides were measured in vitro as well as glycerol and fatty acid release, which allowed us to estimate adipose tissue lipolysis. The amount of fatty acids produced by lipolysis and thereafter utilized within adipose tissue without being released (fatty acid retention) was estimated. Fatty acid and glucose incorporation into adipose tissue, glycerol release and fatty acid retention values increased, but serum triglyceride levels decreased (all P < 0.001) after nicotinic acid treatment. The change in fatty acid incorporation was positively correlated with changes in glucose incorporation into adipose tissue (r = 0.53, P < 0.01) and fatty acid retention (r = 0.76, P < 0.001). Although adipose tissue lipolysis, measured as glycerol release, increased, the lipolyzed fatty acids were retained in adipose tissue, suggesting an enhanced synthesis of glycerides both from exogenous and endogenous sources. The increase in fatty acid incorporation into adipose tissue indicates that the decrease in serum triglyceride levels produced by nicotinic acid treatment may partly be due to the fact that this drug promotes incorporation of fatty acids, derived from lipoprotein-carried triglycerides in the blood, into adipose tissue glycerides.
31名体重稳定的不同类型高脂蛋白血症患者每日服用4克烟酸，持续6周。评估了该疗法对脂肪组织代谢的影响。通过使用皮下脂肪组织活检标本，在体外测量脂肪酸和葡萄糖掺入脂肪组织甘油酯的情况以及甘油和脂肪酸的释放，这使我们能够估计脂肪组织的脂解作用。估计了脂解产生的脂肪酸量以及随后在脂肪组织内被利用而未释放的量（脂肪酸保留）。烟酸治疗后，脂肪酸和葡萄糖掺入脂肪组织、甘油释放和脂肪酸保留值增加，但血清甘油三酯水平降低（所有P<0.001）。脂肪酸掺入的变化与葡萄糖掺入脂肪组织的变化呈正相关（r = 0.53，P<0.01）以及与脂肪酸保留呈正相关（r = 0.76，P<0.001）。尽管以甘油释放衡量的脂肪组织脂解作用增加，但脂解的脂肪酸保留在脂肪组织中，这表明从外源性和内源性来源合成甘油酯均增强。脂肪酸掺入脂肪组织的增加表明，烟酸治疗导致的血清甘油三酯水平降低可能部分是由于该药物促进了血液中脂蛋白携带的甘油三酯衍生的脂肪酸掺入脂肪组织甘油酯。
