即使在没有可检测到的中和抗体的情况下，接种疫苗也能预防体内生长的猫免疫缺陷病毒。
Vaccination protects against in vivo-grown feline immunodeficiency virus even in the absence of detectable neutralizing antibodies.
作者信息
Matteucci D, Pistello M, Mazzetti P, Giannecchini S, Del Mauro D, Zaccaro L, Bandecchi P, Tozzini F, Bendinelli M
机构信息
Department of Biomedicine, University of Pisa, Italy.
出版信息
J Virol. 1996 Jan;70(1):617-22. doi: 10.1128/JVI.70.1.617-622.1996.
Abstract
So far, vaccination experiments against feline immunodeficiency virus have used in vitro-grown virus to challenge the vaccinated hosts. In this study, cats were vaccinated with fixed feline immunodeficiency virus-infected cells and challenged with plasma obtained from cats infected with the homologous virus diluted to contain 10 cat 50% infectious doses. As judged by virus culture, PCRs, and serological analyses performed over an 18-month period after the challenge, all of the vaccinated cats were clearly protected. Interestingly, prior to challenge most vaccines lacked antibodies capable of neutralizing a fresh isolate of the homologous virus.
摘要
到目前为止，针对猫免疫缺陷病毒的疫苗接种实验一直使用体外培养的病毒来攻击接种疫苗的宿主。在本研究中，给猫接种固定的感染猫免疫缺陷病毒的细胞，并用从感染同源病毒的猫身上获取的血浆进行攻击，该血浆经稀释后含有10个猫50%感染剂量。根据攻击后18个月期间进行的病毒培养、聚合酶链反应（PCR）和血清学分析判断，所有接种疫苗的猫都得到了明显的保护。有趣的是，在攻击之前，大多数疫苗缺乏能够中和同源病毒新鲜分离株的抗体。
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