灭活猫免疫缺陷病毒疫苗诱导的针对同源而非异源攻击的保护作用。
Protection against homologous but not heterologous challenge induced by inactivated feline immunodeficiency virus vaccines.
作者信息
Hosie M J, Osborne R, Yamamoto J K, Neil J C, Jarrett O
机构信息
Department of Veterinary Pathology, University of Glasgow, Bearsden, Scotland.
出版信息
J Virol. 1995 Feb;69(2):1253-5. doi: 10.1128/JVI.69.2.1253-1255.1995.
Abstract
Whole inactivated virus vaccines from the FL4 cell line protected against challenge with homologous feline immunodeficiency virus (Petaluma strain) but not against a heterologous FIV isolate (GL-8) which is distinct from the Petaluma strain in virus neutralization. Protection was associated with a type-specific neutralizing antibody response and was retained when the challenge virus was propagated in an unrelated cell line.
摘要
来自FL4细胞系的全灭活病毒疫苗可保护猫免受同源猫免疫缺陷病毒（佩塔卢马毒株）的攻击，但不能抵御异源猫免疫缺陷病毒分离株（GL - 8），该分离株在病毒中和方面与佩塔卢马毒株不同。这种保护作用与型特异性中和抗体反应相关，并且当攻击病毒在无关细胞系中传代时，这种保护作用仍然存在。
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