Noguchi H, Tazawa Y, Nishinomiya F, Takada G
Department of Pediatrics, Akita University School of Medicine, Japan.
Acta Paediatr Jpn. 1995 Oct;37(5):621-5. doi: 10.1111/j.1442-200x.1995.tb03389.x.
To determine hepatic diseases in obese children, biochemically and histologically, 11 obese patients with abnormal serum transaminase activities were subjected to this study. Fat accumulation in the liver was semiquantitatively graded, and histologically the 11 patients were classified into four groups; fatty liver, fatty hepatitis, fatty fibrosis and fatty cirrhosis. All patients had fat deposition in liver specimens, the grade of which did not significantly correlate with the degree of obesity. The grade of fat deposition in the liver specimens also did not significantly correlate with either serum transaminase activities or GOT/GPT ratio. Five patients were grouped into the fatty liver group, three into the fatty hepatitis group, and the remaining three patients into the fatty fibrosis group. However, no significant differences were found among the three histologically classified groups in terms of serum transaminase activities or GOT/GPT ratio. The usefulness of serum transaminase activities and GOT/GPT ratio was limited in predicting the severity of fat deposition or histological abnormality in pediatric obese patients.
为了从生化和组织学方面确定肥胖儿童的肝脏疾病，本研究纳入了11例血清转氨酶活性异常的肥胖患者。对肝脏中的脂肪堆积进行了半定量分级，从组织学上看，这11例患者被分为四组：脂肪肝、脂肪性肝炎、脂肪纤维化和脂肪性肝硬化。所有患者的肝脏标本中均有脂肪沉积，其分级与肥胖程度无显著相关性。肝脏标本中的脂肪沉积分级也与血清转氨酶活性或谷草转氨酶/谷丙转氨酶比值均无显著相关性。5例患者被归入脂肪肝组，3例归入脂肪性肝炎组，其余3例患者归入脂肪纤维化组。然而，在血清转氨酶活性或谷草转氨酶/谷丙转氨酶比值方面，这三个组织学分类组之间未发现显著差异。血清转氨酶活性和谷草转氨酶/谷丙转氨酶比值在预测儿童肥胖患者脂肪沉积的严重程度或组织学异常方面的作用有限。
