Anane R, Bonini M, Grafeille J M, Creppy E E
Laboratoire de Toxicologie et d'Hygiène Appliquée, Université de Bordeaux 2, France.
Arch Toxicol. 1995;69(8):568-71. doi: 10.1007/s002040050214.
Normally, only very small amounts of ingested aluminium are absorbed and accumulated. Despite the percutaneous absorption of many drugs and chemicals, the skin has not been considered as a possible site at which aluminium could enter the body. Application of low aqueous concentrations of aluminium chloride (A1C1(3), 6H20) (0.025-0.1 micrograms/cm2) to healthy shaved Swiss mouse skin for 130 days led to a significant increase in urine, serum and whole brain aluminium, especially in the hippocampus, compared to control animals. This percutaneous uptake and accumulation of aluminium in the brain was greater than that caused by dietary exposure to 2.3 micrograms per day in feed and water. In vitro studies demonstrated the passage of aluminium through viable mouse skin. This study shows for the first time that aluminium is absorbed through the skin of mice in vivo and this contributes to a greater body burden than does oral uptake.
通常情况下，摄入的铝只有极少量会被吸收和积累。尽管许多药物和化学物质可经皮吸收，但皮肤尚未被视为铝可能进入人体的部位。将低浓度的氯化铝（A1C1₃·6H₂O）水溶液（0.025 - 0.1微克/平方厘米）涂抹在健康的剃毛瑞士小鼠皮肤上130天，与对照动物相比，尿液、血清和全脑铝含量显著增加，尤其是海马体中的铝含量。这种经皮吸收并在大脑中积累的铝量大于通过在饲料和水中每日摄入2.3微克铝的饮食暴露所导致的量。体外研究表明铝可穿过有活力的小鼠皮肤。这项研究首次表明铝在体内可通过小鼠皮肤吸收，且这比口服摄取导致的体内负担更大。
