Abbruzzese M, Ferri S, Scarone S
Department of Biomedical and Technological Sciences, University of Milan Medical School, IRCCS at S. Raffaele Hospital, Italy.
Psychiatry Res. 1995 Sep 8;58(1):37-43. doi: 10.1016/0165-1781(95)02670-r.
Wisconsin Card Sorting Test (WCST) performances were studied in 33 patients with obsessive-compulsive disorder (OCD) and 33 age-, sex-, and education-matched normal comparison subjects; the OCD patients were divided into four subgroups on the basis of their symptomatology. Neither the two groups of subjects nor the four OCD subgroups differed on any of the WCST neuropsychological indices. No relationship was demonstrated between test performance and clinical-epidemiological characteristics of the OCD patients. All of the OCD patients were being treated with fluvoxamine maleate, which improves OCD symptoms and could also improve WCST performances. Nevertheless, no remarkable differences in the WCST indices were observed in patients treated with fluvoxamine when compared with patients who had not received a specific therapy for at least 3 weeks. Since the WCST is widely considered sensitive to dysfunction of the dorsolateral prefrontal cortex, our results do not support the involvement of that brain region in OCD.
对33名强迫症（OCD）患者和33名年龄、性别及教育程度相匹配的正常对照受试者进行了威斯康星卡片分类测验（WCST）表现的研究；根据症状学将OCD患者分为四个亚组。两组受试者以及四个OCD亚组在任何WCST神经心理学指标上均无差异。未发现测验表现与OCD患者的临床流行病学特征之间存在关联。所有OCD患者均接受马来酸氟伏沙明治疗，该药物可改善OCD症状，也可能改善WCST表现。然而，与至少3周未接受特定治疗的患者相比，接受氟伏沙明治疗的患者在WCST指标上未观察到显著差异。由于WCST被广泛认为对背外侧前额叶皮质功能障碍敏感，我们的结果不支持该脑区参与OCD的观点。
