来自威尼斯泻湖的脆弱海绵（Dysidea fragilis）中提取的新型细胞毒性甾体化合物。

New cytotoxic steroids from the marine sponge Dysidea fragilis coming from the lagoon of Venice.

作者信息

Aiello A, Fattorusso E, Menna M, Carnuccio R, Iuvone T

机构信息

Dipartimento di Chimica delle Sostanze Naturali, Napoli, Italy.

出版信息

Steroids. 1995 Oct;60(10):666-73. doi: 10.1016/0039-128x(95)00055-u.

DOI:10.1016/0039-128x(95)00055-u

PMID:8539774

Abstract

The sterol composition of the sponge Dysidea fragilis, coming from the lagoon of Venice, has been investigated; our results confirmed the variability of D. fragilis biochemistry. The sponge elaborates, in addition to eight usual 3 beta-hydroxy sterols, thirteen polyhydroxysterols, eight of them (6-13) were novel compounds. Their structures were established by spectroscopic data. New compounds 3 beta,5 alpha,6 beta,7 alpha-tetrahydroxy-cholest-8(9)-en-11-one (8), 3 beta,5 alpha,6 alpha-trihydroxy-9,11-secocholest-7-en-9-one (9) and 3 beta,5 alpha,6 alpha,9 alpha-tetrahydroxy-cholest-7-ene-6-sulfate (11) were proved to be cytotoxic on two different tumor cell lines in vitro.

摘要

对采自威尼斯潟湖的脆弱海绵（Dysidea fragilis）的甾醇成分进行了研究；我们的结果证实了脆弱海绵生物化学的变异性。除了八种常见的3β-羟基甾醇外，该海绵还合成了十三种多羟基甾醇，其中八种（6 - 13）是新化合物。它们的结构通过光谱数据确定。新化合物3β,5α,6β,7α-四羟基胆甾-8(9)-烯-11-酮（8）、3β,5α,6α-三羟基-9,11-断胆甾-7-烯-9-酮（9）和3β,5α,6α,9α-四羟基胆甾-7-烯-6-硫酸盐（11）在体外对两种不同的肿瘤细胞系具有细胞毒性。