由大肠菌素Ia在平面脂质双分子层中形成的水通道的直径。

The diameter of water pores formed by colicin Ia in planar lipid bilayers.

作者信息

Krasilnikov O V, Yuldasheva L N, Nogueira R A, Rodrigues C G

机构信息

Laboratory of Molecular Physiology, Institute of Physiology and Biophysics, Tashkent, Uzbekistan.

出版信息

Braz J Med Biol Res. 1995 Jun;28(6):693-8.

PMID:8547854

Abstract

The effective size of colicin Ia channel was tested by a recently described method (FEMS, Microbiology and Immunology (1992). 105: 93-100) in which the nonelectrolyte molecules with different hydrodynamic diameters (0.52 to 5.0 nm) were used as molecular tools. We have shown that despite low conductance (55-105 pS at 1.5 M KCl, pH 7.0) the ion channels formed by colicin Ia have a fairly large water pore diameter equal to 1.66-1.88 nm. The results are discussed in terms of an energetic barrier for ions passing into the channel lumen.

摘要

通过一种最近描述的方法（《FEMS，微生物学与免疫学》（1992年）。105: 93 - 100）测试了大肠菌素Ia通道的有效尺寸，该方法使用具有不同流体动力学直径（0.52至5.0纳米）的非电解质分子作为分子工具。我们已经表明，尽管电导较低（在1.5 M KCl，pH 7.0时为55 - 105 pS），但由大肠菌素Ia形成的离子通道具有相当大的水孔直径，等于1.66 - 1.88纳米。根据离子进入通道内腔的能量屏障对结果进行了讨论。