Quirinia A, Viidik A
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Mech Ageing Dev. 1991 May;58(2-3):221-32. doi: 10.1016/0047-6374(91)90094-g.
Experimental studies have not shown that the 'common' clinical experience, which suggests that wound healing is impaired in an old organism, is valid for healthy old experimental animals. We have developed a model in the rat for ischemic wound healing by using an H-shaped double skin flap, where the test wound is the horizontal line in the H. Our previous studies have shown that the blood flow in this wound is only 7% of that of a normally vascularized wound on the first postoperative day. Functional (biomechanical) properties of this wound are decreased by up to 67% after 10 days of healing and certain key properties by up to 64% after both 10 and 20 days. This study reports on the effect of aging, using 3- and 24-month-old rats. The 'normal' incisional wounds healed equally well in both groups. On the other hand, the ischemic wounds in the old animals were found to be impaired by 40-65% compared to similar wounds in the young animals. It is concluded that ischemia is deleterious for wound healing in old age and that one of the key elements of the clinical experience of impaired wound healing in old age is probably based on concomitant diseases in old patients, contributing to varying degrees of ischemia in the traumatized tissue.
实验研究并未表明，“常见”的临床经验（即认为老龄生物体的伤口愈合会受损）适用于健康的老龄实验动物。我们通过使用H形双皮瓣在大鼠身上建立了一个缺血性伤口愈合模型，其中测试伤口是H中的横线。我们之前的研究表明，该伤口在术后第一天的血流量仅为正常血管化伤口的7%。愈合10天后，该伤口的功能（生物力学）特性下降高达67%，某些关键特性在10天和20天后分别下降高达64%。本研究报告了使用3个月和24个月大的大鼠进行衰老影响的研究结果。两组的“正常”切口伤口愈合情况相同。另一方面，与年轻动物的类似伤口相比，老龄动物的缺血性伤口受损程度达40%-65%。得出的结论是，缺血对老龄伤口愈合有害，老龄伤口愈合受损的临床经验的关键因素之一可能基于老龄患者的伴随疾病，这些疾病会导致创伤组织不同程度的缺血。
