Clark S P, Arden B, Kabelitz D, Mak T W
Amgen Center, Thousand Oaks, California 91320, USA.
Immunogenetics. 1995;42(6):531-40. doi: 10.1007/BF00172178.
Like the immunoglobulin Igh-V and Igk-V gene families, the human or mouse TCRV gene families may be grouped into subfamilies displaying > 75% nucleic acid sequence similarity among their members. Systematic interspecies sequence comparisons reveal that most mouse Tcr-V subfamilies exhibit clear homology to human TCRV subfamilies (> 60% amino acid sequence similarity). Homologous pairs of TCRV genes in mice and humans show higher sequence similarity than TCRV genes from different subfamilies within either species, indicating transspecies evolution of TCRV genes. Mouse and human homologues show conservation of their relative map order, particularly in the 3' region and a similar sequential and developmentally programmed expression. When the V regions from both species were analyzed together, local length differences and conserved residues in the loop regions were revealed, characteristic of each of the four TCRV families.
与免疫球蛋白Igh-V和Igk-V基因家族一样，人类或小鼠的TCRV基因家族可分为亚家族，其成员之间显示出> 75%的核酸序列相似性。系统的种间序列比较表明，大多数小鼠Tcr-V亚家族与人类TCRV亚家族表现出明显的同源性（> 60%的氨基酸序列相似性）。小鼠和人类中TCRV基因的同源对显示出比任一物种内不同亚家族的TCRV基因更高的序列相似性，表明TCRV基因的跨物种进化。小鼠和人类的同源物显示出它们相对图谱顺序的保守性，特别是在3'区域以及相似的顺序性和发育程序性表达。当一起分析两个物种的V区时，发现了局部长度差异和环区的保守残基，这是四个TCRV家族各自的特征。
