Nicklas B J, Ryan A J, Treuth M M, Harman S M, Blackman M R, Hurley B F, Rogers M A
Department of Kinesiology, University of Maryland, College Park 20742, USA.
Int J Sports Med. 1995 Oct;16(7):445-50. doi: 10.1055/s-2007-973035.
We investigated the responses of serum testosterone (T) and human growth hormone (hGH) concentrations to a bout of heavy resistive exercise and the responses of T, hGH, and insulin-like growth factor I (IGF-I) to a 16 wk progressive resistive training program in 13 men (60 +/- 4 yrs). Body composition via hydrostatic weighing and muscle strength using a 3 repetition maximum (3RM) test on 6 variable resistance exercise machines were assessed before and after the training program. Fasting blood samples were drawn on 2 consecutive days prior to training and again on 2 consecutive days after the last day of exercise. Blood was also drawn immediately before and approximately 10 min after a single exercise session during the first wk of training, and after an exercise session of the same relative resistance during the last wk of training. The training program resulted in a 37% increase in upper body strength and a 39% increase in lower body strength (both p < 0.01). Lean body mass increased significantly (61.8 +/- 2.1 vs 63.7 +/- 7.8 kg; p < 0.001) while % fat decreased (26.5 +/- 1.5 vs 24.9 +/- 6.0%; p < 0.01) as a result of training. Serum T concentration was unchanged, but GH increased approximately 18-fold in response to a single bout of resistive exercise before (0.24 +/- 0.08 vs 4.60 +/- 1.35 mg/l) and after (0.26 +/- 0.06 vs 4.66 +/- 1.46 mg/l; p < 0.01) training. Baseline serum concentrations of T, hGH, and IGF-I were unaffected by the training program. We conclude that an acute bout of resistive exercise causes a substantial hGH response in older men, but 16 wks of progressive resistive training does not affect baseline concentrations of the anabolic hormones.
我们研究了13名男性（60±4岁）血清睾酮（T）和人生长激素（hGH）浓度对一次大强度抗阻运动的反应，以及T、hGH和胰岛素样生长因子I（IGF-I）对为期16周的渐进性抗阻训练计划的反应。在训练计划前后，通过水下称重评估身体成分，并使用6台可变阻力运动器械进行3次重复最大值（3RM）测试来评估肌肉力量。在训练前连续两天以及运动最后一天后的连续两天采集空腹血样。在训练第一周的一次运动前和运动后约10分钟，以及训练最后一周相同相对阻力的运动后，也立即采血。训练计划使上身力量增加了37%，下身力量增加了39%（两者p<0.01）。由于训练，瘦体重显著增加（61.8±2.1 vs 63.7±7.8 kg；p<0.001），而体脂百分比下降（26.5±1.5 vs 24.9±6.0%；p<0.01）。血清T浓度未发生变化，但在训练前（0.24±0.08 vs 4.60±1.35 mg/l）和训练后（0.26±0.06 vs 4.66±1.46 mg/l；p<0.01），hGH对一次抗阻运动的反应增加了约18倍。训练计划未影响T、hGH和IGF-I的基线血清浓度。我们得出结论，一次急性抗阻运动在老年男性中会引起显著的hGH反应，但16周的渐进性抗阻训练不会影响合成代谢激素的基线浓度。
