Bcl-2阳性扁桃体浆细胞可通过骨髓成纤维细胞免于凋亡。
Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts.
作者信息
Merville P, Déchanet J, Desmoulière A, Durand I, de Bouteiller O, Garrone P, Banchereau J, Liu Y J
机构信息
Schering-Plough Laboratory for Immunological Research, Dardilly, France.
出版信息
J Exp Med. 1996 Jan 1;183(1):227-36. doi: 10.1084/jem.183.1.227.
Plasma cells represent the final stage of B lymphocyte differentiation. Most plasma cells in secondary lymphoid tissues live for a few days, whereas those in the lamina propria of mucosa and in bone marrow live for several weeks. To investigate the regulation of human plasma cell survival, plasma cells were isolated from tonsils according to high CD38 and low CD20 expression. Tonsillar plasma cells express CD9, CD19, CD24, CD37, CD40, CD74, and HLA-DR, but not CD10, HLA-DQ, CD28, CD56, and Fas/CD95. Although plasma cells express intracytoplasmic Bcl-2, they undergo swift apoptosis in vitro and do not respond to CD40 triggering. Bone marrow fibroblasts and rheumatoid synoviocytes, however, prevented plasma cells from undergoing apoptosis in a contact-dependent fashion. These data indicate that fibroblasts may form a microenvironment favorable for plasma cell survival under normal and pathological conditions.
浆细胞代表B淋巴细胞分化的终末阶段。次级淋巴组织中的大多数浆细胞存活数天，而黏膜固有层和骨髓中的浆细胞则存活数周。为了研究人类浆细胞存活的调节机制，根据高CD38和低CD20表达从扁桃体中分离出浆细胞。扁桃体浆细胞表达CD9、CD19、CD24、CD37、CD40、CD74和HLA-DR，但不表达CD10、HLA-DQ、CD28、CD56和Fas/CD95。尽管浆细胞表达胞浆内Bcl-2，但它们在体外迅速凋亡，且对CD40触发无反应。然而，骨髓成纤维细胞和类风湿性滑膜细胞以接触依赖的方式阻止浆细胞凋亡。这些数据表明，成纤维细胞可能在正常和病理条件下形成有利于浆细胞存活的微环境。
Zotero 插件