从沙特阿拉伯的英国军队中分离出产肠毒素大肠杆菌。
Isolation of enterotoxigenic Escherichia coli from British troops in Saudi Arabia.
作者信息
Willshaw G A, Cheasty T, Rowe B, Smith H R, Faithfull-Davies D N, Brooks T G
机构信息
Laboratory of Enteric Pathogens, Central Public Health Laboratory, London, UK.
出版信息
Epidemiol Infect. 1995 Dec;115(3):455-63. doi: 10.1017/s0950268800058611.
Specimens from 181 patients with diarrhoea were examined by a Military General Hospital in a 3-month period during deployment of troops to Saudi Arabia in 1990/1. DNA probes for heat labile (LT) and heat stable (ST) enterotoxin genes identified enterotoxigenic Escherichia coli (ETEC) in 47 of the specimens (26%) and 49 ETEC strains were isolated. The majority (55%) belonged to a novel ETEC serotype having the O-antigen 159 and a flagellar antigen designated as a provisional new type. They produced ST and the coli surface associated antigen (CS)6. Strains of serotype O6:H16 represented 22% of the ETEC examined. They produced ST, LT and CS3 together with either CS1 or CS2. The remaining ETEC belonged to seven O:H serotypes. Overall, ST was the only enterotoxin gene identified in 73% of the ETEC and 67% of the strains expressed CS6 in the absence of other colonization antigens. Resistance to three or more antibiotics was observed in 53% of the ETEC, including most of the O159 strains.
1990/1年部队部署到沙特阿拉伯期间，一家军队总医院在3个月内对181例腹泻患者的标本进行了检查。用于检测不耐热（LT）和耐热（ST）肠毒素基因的DNA探针在47份标本（26%）中鉴定出产肠毒素大肠杆菌（ETEC），并分离出49株ETEC菌株。大多数（55%）属于一种新型ETEC血清型，具有O抗原159和一种被指定为暂定新型的鞭毛抗原。它们产生ST和菌毛表面相关抗原（CS）6。O6:H16血清型菌株占所检测ETEC的22%。它们同时产生ST、LT和CS3以及CS1或CS2。其余的ETEC属于7种O:H血清型。总体而言，ST是73%的ETEC中唯一鉴定出的肠毒素基因，67%的菌株在没有其他定植抗原的情况下表达CS6。53%的ETEC观察到对三种或更多抗生素耐药，包括大多数O159菌株。
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