Rakicidins, new cytotoxic lipopeptides from Micromonospora sp. fermentation, isolation and characterization.

作者信息

McBrien K D, Berry R L, Lowe S E, Neddermann K M, Bursuker I, Huang S, Klohr S E, Leet J E

机构信息

Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.

出版信息

J Antibiot (Tokyo). 1995 Dec;48(12):1446-52. doi: 10.7164/antibiotics.48.1446.

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid, 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the M109 cell line.