白细胞介素-6诱导的大鼠贫血：对慢性炎症中观察到的贫血可能的发病机制影响
IL-6-induced anaemia in rats: possible pathogenetic implications for anemia observed in chronic inflammations.
作者信息
Jongen-Lavrencic M, Peeters H R, Rozemuller H, Rombouts W J, Martens A C, Vreugdenhil G, Pillay M, Cox P H, Bijser M, Brutel G, Breedveld F C, Swaak A J
机构信息
Department of Rheumatology, Dr Daniel den Hoed Clinic, Rotterdam, The Netherlands.
出版信息
Clin Exp Immunol. 1996 Feb;103(2):328-34. doi: 10.1046/j.1365-2249.1996.d01-622.x.
Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 in the pathogenesis of this anaemia was investigated. IL-6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL-6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with 99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL-6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.
慢性病性贫血（ACD）在类风湿关节炎（RA）中很常见。在ACD的发病机制中，诸如肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）和白细胞介素-6等细胞因子以及促红细胞生成素（EPO）的相对缺乏都被认为起着关键作用。在本研究中，对白细胞介素-6在这种贫血发病机制中的作用进行了研究。连续14天腹腔注射白细胞介素-6给大鼠。结果显示白细胞介素-6能够诱发贫血。未发现骨髓红细胞生成受抑制或肝脏中红细胞滞留增加的证据。然而，在贫血大鼠中观察到血浆和骨髓铁含量降低。使用99m锝标记红细胞证实肠道组织有失血。组织学上，这与肠壁炎症细胞浸润、水肿和出血有关。总之，白细胞介素-6可诱发大鼠贫血。这种贫血是由肠道失血引起的。
Zotero 插件