Qasim S M, Trias A, Sachdev R, Kemmann E
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, New Brunswick 08901, USA.
Fertil Steril. 1996 Feb;65(2):443-5. doi: 10.1016/s0015-0282(16)58114-x.
To analyze whether increased serum creatine kinase (CK) levels are useful in early detection of ectopic pregnancy (EP).
Prospective cohort study.
Patients in a university-based reproductive endocrinology and infertility practice.
Infertile women who achieved clinical pregnancy.
Serum CK with isoenzymes levels were drawn after sonographic evaluation in patients achieving clinical pregnancy.
Comparison of serum CK levels in patients with EP versus those with normal and abnormal intrauterine pregnancy (IUP), both separately and together as one group.
There was no significant difference in mean total CK levels for patients with EP (82.25 +/- 81.39 IU/L; conversion factor to SI unit, 1.00) versus normal IUP (62.54 +/- 44.79 IU/L), abnormal IUP (55.15 +/- 3.46 IU/L), or all IUP (60.87 +/- 40.72 IU/L). The mean gestational ages were similar in all three groups: EP, 46.78 +/- 6.65 days; normal IUP, 47.56 +/- 8.29 days; and abnormal IUP, 47.86 +/- 13.30 days.
Serum CK levels do not help to predict EP for infertility patients achieving conception. To assist in preventing maternal morbidity, a more discriminative test is needed to identify this condition early in gestation.
分析血清肌酸激酶（CK）水平升高是否有助于早期检测异位妊娠（EP）。
前瞻性队列研究。
一所大学的生殖内分泌与不孕症诊所的患者。
实现临床妊娠的不孕女性。
对实现临床妊娠的患者进行超声评估后抽取血清CK及其同工酶水平。
比较异位妊娠患者与正常和异常宫内妊娠（IUP）患者的血清CK水平，分别比较以及将正常和异常IUP患者作为一组进行比较。
异位妊娠患者的平均总CK水平（82.25±81.39 IU/L；转换为国际单位制的转换因子为1.00）与正常宫内妊娠（62.54±44.79 IU/L）、异常宫内妊娠（55.15±3.46 IU/L）或所有宫内妊娠（60.87±40.72 IU/L）患者相比，无显著差异。三组的平均孕周相似：异位妊娠为46.78±6.65天；正常宫内妊娠为47.56±8.29天；异常宫内妊娠为47.86±13.30天。
血清CK水平无助于预测受孕的不孕患者是否为异位妊娠。为了帮助预防孕产妇发病，需要一种更具鉴别性的检测方法来在妊娠早期识别这种情况。
