Montes H, Berrueta L, Cova J, Salmen S, Arribas C, Donis J, Hernandez M
Centro Ambulatorio Médico Odontológico de la Universidad de Los Andes, Mérida, Venezuela.
G E N. 1995 Apr-Jun;49(2):132-9.
We have done a study in order two know the prevalence of anti-hepatitis C virus antibodies in polytransfused patients with hemophilia, leukemia and hemolytic anemia, along with 17 healthy donors, without previous history of transfusions. We analyzed samples from 10 hemophilic patients and 12 from leukemia, lymphoma and hemolytic anemia, all of them had received blood or blood products, at least six months before the study. Using a second generation ELISA, 4 positive sample (3 hemophilic and 1 lymphoma) were detected (10.26%), which represent a prevalence of 30% in the hemophilic group, in contrast with the prevalence detected in other countries. A very significant statistic association was demonstrated, between the positive ELISA, the amount of the transfused product (P < 0.0004) and the type of blood product used for transfusion (crioprecipited, P = 0.000, plasma P = 0.000).
我们进行了一项研究，旨在了解血友病、白血病和溶血性贫血的多次输血患者以及17名无输血史的健康供者中抗丙型肝炎病毒抗体的流行情况。我们分析了10名血友病患者以及12名白血病、淋巴瘤和溶血性贫血患者的样本，所有这些患者在研究前至少六个月都接受过血液或血液制品。使用第二代酶联免疫吸附测定法（ELISA），检测到4份阳性样本（3份来自血友病患者，1份来自淋巴瘤患者）（占10.26%），这表明血友病组的流行率为30%，与其他国家检测到的流行率形成对比。在ELISA阳性结果、输血制品的量（P < 0.0004）和用于输血的血液制品类型（冷沉淀，P = 0.000；血浆，P = 0.000）之间显示出非常显著的统计学关联。
