Wrbitzky R, Drexler H, Letzel S
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University of Erlangen-Nürnberg, Germany.
Int Arch Occup Environ Health. 1995;67(6):413-7. doi: 10.1007/BF00381054.
The prevalence of positive skin-prick test reactions ammonium persulphate and potassium persulphate (1% and 5% solutions) was tested in a cross-sectional study on 52 employees of a company producing persulphates after a case of "persulphate asthma" was observed. A random test of 13 persons without occupational exposure to persulphates served as controls; among them all the skin-prick test reactions were negative. Eight company employees showed a positive skin-prick test reaction to at least one of the persulphate solutions tested. Employees showed lower lung function results with a positive prick test reaction than did employees with a negative result. The positive skin-prick reactions correspond well to the anamnestic data and indicate a possible relationship to obstructive ventilation disorders. The results therefore suggest an IgE-induced, allergic pathomechanism of "persulphate asthma" triggered by persulphates.
在观察到一例“过硫酸盐哮喘”病例后，对一家生产过硫酸盐的公司的52名员工进行了一项横断面研究，检测了他们对过硫酸铵和过硫酸钾（1%和5%溶液）的皮肤点刺试验阳性反应的患病率。随机抽取13名无职业性过硫酸盐接触史的人员作为对照进行检测；他们所有人的皮肤点刺试验反应均为阴性。该公司有8名员工对至少一种所检测的过硫酸盐溶液表现出皮肤点刺试验阳性反应。与皮肤点刺试验反应阴性的员工相比，反应阳性的员工肺功能结果更低。皮肤点刺试验阳性反应与既往病史数据吻合良好，提示可能与阻塞性通气障碍有关。因此，结果表明过硫酸盐引发的“过硫酸盐哮喘”存在IgE介导的过敏发病机制。
