• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一种使用前馈外毛细胞力的耳蜗模型。

A cochlear model using feed-forward outer-hair-cell forces.

作者信息

Geisler C D, Sang C

机构信息

Department of Neurophysiology, University of Wisconsin-Madison 53706, USA.

出版信息

Hear Res. 1995 Jun;86(1-2):132-46. doi: 10.1016/0378-5955(95)00064-b.

DOI:10.1016/0378-5955(95)00064-b
PMID:8567410
Abstract

A linear (frequency-domain) model of the cat cochlea (implemented in both 1- and 2-dimensional versions) has been developed which uses outer hair cell (OHC) forces in a geometry which includes the longitudinal (base-to-apex) tilt of the outer hair cells (OHCs). When positive (contractile) real OHC force-constants are used, very large (50 + dB) response peaks along with very rapidly accumulating phase lags (which can reach -50 pi radians) are obtained. The wider the longitudinal segmentation, the broader the peaks and the less the phase accumulation; 71-microns segmentation produced the most realistic responses. These large response peaks are achieved by a small zone of negative resistance (ca. 1 mm) just basal to the response peak and the virtual 'zeroing' of the basilar membrane's effective impedance over the entire peak region (ca. 2.5 mm). To produce these peaks, the OHCs generate about 25-times the incoming acoustic power. Inclusion of low-pass filtering in the model's OHC representation produces, by contrast, very unrealistic notch-and-peak displacement complexes accompanied by very large phase lags, for all segmentation widths used. However, when phase reversals of OHC forces are also added, achieved by imbedding a resonant system within the tectorial membrane, very realistic peaks and phase functions are produced. More power must, however, be generated by the OHCs (about 70-times the incoming). The end result is output which mimics quite closely the living basilar membrane's responses to low-intensity high-frequency tones.

摘要

已经开发出一种猫耳蜗的线性(频域)模型(有一维和二维版本),该模型在一种几何结构中使用外毛细胞(OHC)力,这种几何结构包括外毛细胞的纵向(从基部到顶部)倾斜。当使用正的(收缩性的)实际OHC力常数时,会获得非常大(50 + dB)的响应峰值以及非常快速累积的相位滞后(可达到 -50π 弧度)。纵向分割越宽,峰值越宽且相位累积越少;71微米的分割产生了最逼真的响应。这些大的响应峰值是通过在响应峰值基部刚好有一个小的负阻区域(约1毫米)以及在整个峰值区域(约2.5毫米)基底膜有效阻抗的虚拟“归零”来实现的。为了产生这些峰值,OHC产生的功率约为入射声功率的25倍。相比之下,在模型的OHC表示中包含低通滤波,对于所有使用的分割宽度,都会产生非常不现实的凹口和峰值位移复合体以及非常大的相位滞后。然而,当通过在盖膜内嵌入一个共振系统来添加OHC力的相位反转时,会产生非常逼真的峰值和相位函数。然而,OHC必须产生更多的功率(约为入射功率的70倍)。最终结果是输出非常接近活体基底膜对低强度高频音调的响应。

相似文献

1
A cochlear model using feed-forward outer-hair-cell forces.一种使用前馈外毛细胞力的耳蜗模型。
Hear Res. 1995 Jun;86(1-2):132-46. doi: 10.1016/0378-5955(95)00064-b.
2
A realizable cochlear model using feedback from motile outer hair cells.一种利用活动外毛细胞反馈的可实现的耳蜗模型。
Hear Res. 1993 Aug;68(2):253-62. doi: 10.1016/0378-5955(93)90129-o.
3
Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces.沿小鼠耳蜗的行波放大和抑制:外毛细胞产生力的纵向耦合空间变化的证据。
J Neurosci. 2019 Mar 6;39(10):1805-1816. doi: 10.1523/JNEUROSCI.2608-18.2019. Epub 2019 Jan 16.
4
A cochlear model using feedback from motile outer hair cells.一种利用能动外毛细胞反馈的耳蜗模型。
Hear Res. 1991 Jul;54(1):105-17. doi: 10.1016/0378-5955(91)90140-5.
5
Timing of cochlear feedback: spatial and temporal representation of a tone across the basilar membrane.耳蜗反馈的时机:基底膜上音调的空间和时间表征。
Nat Neurosci. 1999 Jul;2(7):642-8. doi: 10.1038/10197.
6
How can the cochlear amplifier be realized by the outer hair cells which have nothing to push against?没有支撑物的外毛细胞是如何实现耳蜗放大器功能的呢?
Hear Res. 2002 Oct;172(1-2):53-61. doi: 10.1016/s0378-5955(02)00455-0.
7
Modeling the active process of the cochlea: phase relations, amplification, and spontaneous oscillation.模拟耳蜗的主动过程:相位关系、放大作用和自发振荡。
Biophys J. 1995 Jul;69(1):138-47. doi: 10.1016/S0006-3495(95)79883-6.
8
Local mechanical properties of mouse outer hair cells: atomic force microscopic study.小鼠外毛细胞的局部力学特性:原子力显微镜研究
Auris Nasus Larynx. 2006 Jun;33(2):149-57. doi: 10.1016/j.anl.2005.11.009. Epub 2006 Jan 24.
9
How are inner hair cells stimulated? Evidence for multiple mechanical drives.内毛细胞是如何被刺激的?多种机械驱动的证据。
Hear Res. 2012 Oct;292(1-2):35-50. doi: 10.1016/j.heares.2012.08.005. Epub 2012 Aug 24.
10
Optimal electrical properties of outer hair cells ensure cochlear amplification.外毛细胞的最佳电性能确保了耳蜗的放大作用。
PLoS One. 2012;7(11):e50572. doi: 10.1371/journal.pone.0050572. Epub 2012 Nov 27.

引用本文的文献

1
The spatial buildup of nonlinear compression in the cochlea.耳蜗中非线性压缩的空间积累。
Front Cell Neurosci. 2025 Jan 29;18:1450115. doi: 10.3389/fncel.2024.1450115. eCollection 2024.
2
Optogenetics Reveals Roles for Supporting Cells in Force Transmission to and From Outer Hair Cells in the Mouse Cochlea.光遗传学揭示了支持细胞在小鼠耳蜗中力传递到和来自外毛细胞的作用。
J Neurosci. 2024 Jan 24;44(4):e1179232023. doi: 10.1523/JNEUROSCI.1179-23.2023.
3
Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification.
耳声发射揭示了耳蜗放大中 Corti 器官细胞结构的微观机械作用。
Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2305921120. doi: 10.1073/pnas.2305921120. Epub 2023 Oct 5.
4
Microstructural interactions contribute to the hotspot in the living cochlea.微观结构相互作用导致了活体耳蜗中的热点。
Curr Res Neurobiol. 2022 Jun 20;3:100045. doi: 10.1016/j.crneur.2022.100045. eCollection 2022.
5
Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model.有限元小鼠模型中的刺激频率耳声发射和中耳压力增益
J Acoust Soc Am. 2022 Nov;152(5):2769. doi: 10.1121/10.0014901.
6
Broadband nonreciprocal linear acoustics through a non-local active metamaterial.通过非局部有源超材料实现的宽带非互易线性声学
New J Phys. 2020 Jun;22(6). doi: 10.1088/1367-2630/ab8aad.
7
Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.毛细胞支持细胞需要 GAS2 来维持细胞骨架结构和听力。
Dev Cell. 2021 May 17;56(10):1526-1540.e7. doi: 10.1016/j.devcel.2021.04.017. Epub 2021 May 7.
8
Nonlinear cochlear mechanics without direct vibration-amplification feedback.无直接振动放大反馈的非线性耳蜗力学
Phys Rev Res. 2020 Feb-Apr;2(1). doi: 10.1103/physrevresearch.2.013218. Epub 2020 Feb 26.
9
Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces.沿小鼠耳蜗的行波放大和抑制:外毛细胞产生力的纵向耦合空间变化的证据。
J Neurosci. 2019 Mar 6;39(10):1805-1816. doi: 10.1523/JNEUROSCI.2608-18.2019. Epub 2019 Jan 16.
10
Vibration hotspots reveal longitudinal funneling of sound-evoked motion in the mammalian cochlea.振动热点揭示了哺乳动物耳蜗中声激发运动的纵向集中。
Nat Commun. 2018 Aug 3;9(1):3054. doi: 10.1038/s41467-018-05483-z.