Antaki J F, Dennis T J, Konishi H, Brown M E, Maher T R, Tomczak J P, Kerrigan J P, Kormos R L
University of Pittsburgh, Artificial Heart and Lung Program, Pennsylvania 15219, USA.
Artif Organs. 1995 Jul;19(7):671-5. doi: 10.1111/j.1525-1594.1995.tb02400.x.
Ventricular unloading with dynamic blood pumps can be markedly affected by the geometry of the cannula tip within the ventricular chamber. Due to the ability of these pumps to develop significant negative inflow pressure, existing cannula tips designed for passively filling blood pumps can be predisposed to inflow occlusion by intraventricular anatomic structures. A novel "trumpet" mouth cannula was constructed to overcome this limiting problem. This design was based on two criteria: to provide additional stenting to the ventricular apex, and to assure placement of the tip opening relative to the endocardial surface. This prototype cannula was evaluated in vivo against conventional caged, blunt, and tapered designs to assess anatomic and hemodynamic interaction within the ventricular apex. Post mortem examination revealed the inflow tract to be devoid of myocardial obstruction in all cases. These initial studies indicate that a trumpet mouth cannula can provide satisfactory hemodynamic performance required by dynamic blood pumps.
动态血泵进行心室卸载会受到心室内插管尖端几何形状的显著影响。由于这些血泵能够产生显著的负流入压力，现有的为被动充盈血泵设计的插管尖端可能易被心室内解剖结构导致流入道阻塞。一种新型的“喇叭口”插管被制造出来以克服这一限制问题。这种设计基于两个标准：为心尖提供额外的支撑，以及确保尖端开口相对于心内膜表面的位置。该原型插管在体内与传统的笼式、钝头和锥形设计进行了评估，以评估心尖内的解剖和血流动力学相互作用。尸检显示所有病例的流入道均无心肌梗阻。这些初步研究表明，喇叭口插管能够提供动态血泵所需的令人满意的血流动力学性能。
