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1995年钝性肝损伤的非手术治疗现状:404例患者的多中心经验

Status of nonoperative management of blunt hepatic injuries in 1995: a multicenter experience with 404 patients.

作者信息

Pachter H L, Knudson M M, Esrig B, Ross S, Hoyt D, Cogbill T, Sherman H, Scalea T, Harrison P, Shackford S

机构信息

Department of Surgery, New York University/Bellevue Hospital, New York, USA.

出版信息

J Trauma. 1996 Jan;40(1):31-8. doi: 10.1097/00005373-199601000-00007.

Abstract

Nonoperative management is presently considered the treatment modality of choice in over 50% of adult patients sustaining blunt hepatic trauma who meet inclusion criteria. A multicenter study was retrospectively undertaken to assess whether the combined experiences at level I trauma centers could validate the currently reported high success rate, low morbidity, and virtually nonexistent mortality associated with this approach. Thirteen level I trauma centers accrued 404 adult patients sustaining blunt hepatic injuries managed nonoperatively over the last 5 years. Seventy-two percent of the injuries resulted from motor vehicle crashes. The mean injury severity score for the entire group was 20.2 (range, 4-75), and the American Association for the Surgery of Trauma-computerized axial tomography scan grading was as follows: grade I, 19% (n = 76); grade II, 31% (n = 124); grade III, 36% (n = 146); grade IV, 10% (n = 42); and grade V, 4% (n = 16). There were 27 deaths (7%) in the series, with 59% directly related to head trauma. Only two deaths (0.4%) could be attributed to hepatic injury. Twenty-one (5%) complications were documented, with the most common being hemorrhage, occurring in 14 (3.5%). Only 3 (0.7%) of these 14 patients required surgical intervention, 6 were treated by transfusions alone (0.5 to 5 U), 4 underwent angio-embolization, and 1 was further observed. Other complications included 2 bilomas and 3 perihepatic abscesses (all drained percutaneously). Two small bowel injuries were initially missed (0.5%), and diagnosed 2 and 3 days after admission. Overall, 6 patients required operative intervention: 3 for hemorrhage, 2 for missed enteric injuries, and 1 for persistent sepsis after unsuccessful percutaneous drainage. Average length of stay was 13 days. Nonoperative management of blunt hepatic injuries is clearly the treatment modality of choice in hemodynamically stable patients, irrespective of grade of injury or degree of hemoperitoneum. Current data would suggest that 50 to 80% (47% in this series) of all adult patients with blunt hepatic injuries are candidates for this form of therapy. Exactly 98.5% of patients analyzed in this study successfully avoided operative intervention. Bleeding complications are infrequently encountered (3.5%) and can often be managed nonoperatively. Although grades IV and V injuries composed 14% of the series, they represented 66.6% of the patients requiring operative intervention and thus merit constant re-evaluation and close observation in critical care units. The optimal time for follow-up computerized axial tomography scanning seems to be within 7 to 10 days after injury.

摘要

目前,非手术治疗被认为是超过50%符合纳入标准的钝性肝外伤成年患者的首选治疗方式。一项多中心研究进行了回顾性分析,以评估一级创伤中心的综合经验能否证实目前报道的这种治疗方法具有高成功率、低发病率以及几乎不存在死亡率。13家一级创伤中心收集了过去5年中404例接受非手术治疗的钝性肝损伤成年患者的数据。72%的损伤由机动车碰撞所致。整个队列的平均损伤严重程度评分为20.2(范围4 - 75),美国创伤外科学会计算机断层扫描分级如下:I级,19%(n = 76);II级,31%(n = 124);III级,36%(n = 146);IV级,10%(n = 42);V级,4%(n = 16)。该队列中有27例死亡(7%),其中59%与头部创伤直接相关。仅有2例死亡(0.4%)可归因于肝损伤。记录到21例(5%)并发症,最常见的是出血,有14例(3.5%)。这14例患者中仅3例(0.7%)需要手术干预,6例仅通过输血治疗(0.5至5单位),4例接受血管栓塞治疗,1例进一步观察。其他并发症包括2例胆汁瘤和3例肝周脓肿(均经皮引流)。最初漏诊了2例小肠损伤(0.5%),分别在入院后2天和3天确诊。总体而言,6例患者需要手术干预:3例因出血,2例因漏诊的肠道损伤,1例因经皮引流失败后持续脓毒症。平均住院时间为13天。钝性肝损伤的非手术治疗显然是血流动力学稳定患者的首选治疗方式,无论损伤分级或腹腔积血程度如何。目前的数据表明,所有钝性肝损伤成年患者中有50%至80%(本系列中为47%)适合这种治疗方式。本研究中分析的患者恰好98.5%成功避免了手术干预。出血并发症很少见(3.5%),且通常可通过非手术治疗。尽管IV级和V级损伤占该系列的14%,但它们占需要手术干预患者的66.6%,因此在重症监护病房需要持续重新评估并密切观察。随访计算机断层扫描的最佳时间似乎是受伤后7至10天内。

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