Steingrímsdóttir T, Ronquist G, Ulmsten U, Waldenström A
Department of Obstetrics and Gynecology, Uppsala University Hospital, Sweden.
Eur J Obstet Gynecol Reprod Biol. 1995 Oct;62(2):241-5. doi: 10.1016/0301-2115(95)02195-d.
To study the energy metabolite pattern in term pregnant myometrium and to compare it with that of a striated skeletal muscle.
Metabolites of carbohydrates, triglycerides and nucleotides were determined in biopsies from myometrium and rectus abdominis muscle from ten healthy term pregnant women before onset of labour. The metabolite concentrations in the two types of muscle were compared by two tailed Student's t-test for paired values and correlations were calculated by Pearsson's correlation test.
Comparison of the two muscle types revealed a higher concentration of glucose and a higher lactate/pyruvate ratio in the myometrium but a lower concentration of triglyceride metabolites. Adenosine was found in 36-fold higher concentration in the uterine compared with the rectus muscle and an inverse relationship between adenosine and glucose concentrations was observed in the myometrium.
The results indicated that the pregnant uterine smooth muscle utilized glucose as the principal nutritive metabolite rather than lipids and that the anaerobic pathway of the glucose metabolism was more active in the myometrium compared with the striated rectus muscle. Also, it is suggested that glucose has a critical role as the principal fuel for ATP formation and the involvement of the adenylate kinase and 5'-nucleotidase reactions in any event of glucose shortage.
研究足月妊娠子宫肌层的能量代谢模式，并将其与横纹肌进行比较。
在10名健康足月孕妇临产前，对其子宫肌层和腹直肌活检组织中的碳水化合物、甘油三酯和核苷酸代谢产物进行测定。通过双尾配对t检验比较两种肌肉类型中的代谢产物浓度，并通过Pearson相关检验计算相关性。
两种肌肉类型的比较显示，子宫肌层中葡萄糖浓度较高，乳酸/丙酮酸比值较高，但甘油三酯代谢产物浓度较低。发现子宫中腺苷浓度比腹直肌高36倍，且在子宫肌层中观察到腺苷与葡萄糖浓度呈负相关。
结果表明，妊娠子宫平滑肌利用葡萄糖作为主要营养代谢产物而非脂质，并且与横纹腹直肌相比，子宫肌层中葡萄糖代谢的无氧途径更活跃。此外，提示葡萄糖作为ATP形成的主要燃料具有关键作用，并且在任何葡萄糖短缺情况下，腺苷酸激酶和5'-核苷酸酶反应都会参与其中。
