Swan S H, Beaumont J J, Hammond S K, VonBehren J, Green R S, Hallock M F, Woskie S R, Hines C J, Schenker M B
Department of Epidemiology, School of Public Health, University of California, Berkely 94720, USA.
Am J Ind Med. 1995 Dec;28(6):751-69. doi: 10.1002/ajim.4700280610.
Risk of spontaneous abortion (SAB) was examined in relation to chemical and physical agents in a retrospective study of employees of 14 seminconductor manufacturers: After screening over 6,000 employees, 506 current and 385 former workers were eligible. If a woman had multiple eligible pregnancies, one was selected at random. Telephone interviews provided data on demographics and occupational and other exposures during the first trimester. Two groups of chemicals accounted for the 45% excess risk of SAB among fabrication-room (fab) workers: photoresist and developed solvents (PDS), including glycol ethers, and fluoride compounds used in etching. Women exposed to high levels of both these agents were at greater risk (RR = 3.21, 95% confidence interval [CI] = 1.29-5.96). In fab workers without these exposures, SAB rates were not elevated (adjusted relative risk [RR] = 0.98, 95% CI = 0.55-1.69). An association was seen with workplace stress, which was not limited to women exposed to PDS or fluoride, nor did stress explain the associations between these chemicals and SAB.
在一项针对14家半导体制造商员工的回顾性研究中，研究了自然流产（SAB）风险与化学和物理因素的关系：在对6000多名员工进行筛查后，506名在职员工和385名离职员工符合条件。如果一名女性有多次符合条件的怀孕情况，则随机选择其中一次。电话访谈提供了有关人口统计学以及孕早期职业和其他暴露情况的数据。两类化学物质导致了制造车间（fab）工人中SAB风险增加45%：光刻胶和显影溶剂（PDS），包括乙二醇醚，以及蚀刻中使用的氟化物。同时接触这两种物质高剂量的女性风险更高（相对风险[RR]=3.21，95%置信区间[CI]=1.29 - 5.96）。在没有这些暴露的fab工人中，SAB发生率没有升高（调整后相对风险[RR]=0.98，95%CI=0.55 - 1.69）。研究发现工作场所压力与之存在关联，这种关联并不局限于接触PDS或氟化物的女性，压力也无法解释这些化学物质与SAB之间的关联。
