Gold E B, Eskenazi B, Hammond S K, Lasley B L, Samuels S J, O'Neill Rasor M, Hines C J, Overstreet J W, Schenker M B
Department of Internal Medicine, School of Medicine, University of California, Davis 95616-8638, USA.
Am J Ind Med. 1995 Dec;28(6):799-815. doi: 10.1002/ajim.4700280613.
Women aged 18-44 years in silicon-wafer fabrication-room (fab) jobs and frequency-matched women in nonfab jobs were screened for a prospective study of reproductive health (n = 2,639). Among the 739 (28%) eligible women, 481 (65%) completed a baseline interview; 402 completed at least one menstrual cycle of follow-up with daily diaries and urinary assays to exclude conceptive cycles. Adjusted mean cycle lengths (MCL) did not differ between fab and nonfab women (p = 0.97). Women working in thin film and ion implantation (TFII) had the highest adjusted MCL (34.8 +/- 1.7 days) compared with nonfab workers (32.5 +/- 1.4 days, p = 0.07). Among women working exclusively in one group, TFII women had significantly higher MCL (36.1 +/- 2.04 days) than nonfab women (32.0 +/- 1.38 days, p = 0.017). TFII women were also more likely to have all cycles > 35 days (adjusted relative risk [RR] = 2.45; 95% CI = 0.85-6.06). Variability was assessed by logarithmic transformation of the mean standard deviation (MLSD) in cycle length per woman and adjusted for age and ethnicity (4.5 days for fab vs. 4.0 days for nonfab, p = 0.16). Women working exclusively in TFII or photolithography (PHOTO) had significantly higher adjusted MLSD in cycle length (6.68 +/- 1.28 and 5.72 +/- 1.24 days, respectively) than women in nonfab (4.1 +/- 1.16 days, p = 0.013 and 0.019, respectively). Fab and nonfab women did not differ significantly in mean days of bleeding or risk of having cycles > 35 or < 24 days. However, elevated risks of having cycles < 24 days were seen in supervisor engineers (adjusted RR = 2.46, 95% CI = 1.19-3.63) and PHOTO women (adjusted RR = 1.83, 95% CI = 0.94-2.88).
对在硅片制造车间（fab）工作的18 - 44岁女性以及在非fab工作岗位上频率匹配的女性进行筛查，以开展一项生殖健康前瞻性研究（n = 2,639）。在739名（28%）符合条件的女性中，481名（65%）完成了基线访谈；402名完成了至少一个月经周期的随访，通过每日日记和尿液检测来排除受孕周期。fab组和非fab组女性的调整后平均周期长度（MCL）无差异（p = 0.97）。与非fab组工人（32.5 ± 1.4天，p = 0.07）相比，从事薄膜和离子注入（TFII）工作的女性调整后MCL最高（34.8 ± 1.7天）。在仅在一组工作的女性中，TFII组女性的MCL显著高于非fab组女性（36.1 ± 2.04天对32.0 ± 1.38天，p = 0.017）。TFII组女性也更有可能所有周期均> 35天（调整后相对风险[RR] = 2.45；95%置信区间[CI] = 0.85 - 6.06）。通过对每位女性周期长度的平均标准差进行对数转换（MLSD）来评估变异性，并对年龄和种族进行调整（fab组为4.5天，非fab组为4.0天，p = 0.16）。仅从事TFII或光刻（PHOTO）工作的女性在周期长度上的调整后MLSD显著高于非fab组女性（分别为6.68 ± 1.28天和5.72 ± 1.24天对4.1 ± 1.16天，p分别为0.013和0.019）。fab组和非fab组女性在平均出血天数或周期> 35天或< 24天的风险方面无显著差异。然而，主管工程师（调整后RR = 2.46，95% CI = 1.19 - 3.63）和PHOTO组女性（调整后RR = 1.83，95% CI = 0.94 - 2.88）出现周期< 24天的风险升高。
