• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
p53 gene mutation: software and database.p53基因突变：软件与数据库
Nucleic Acids Res. 1996 Jan 1;24(1):147-50. doi: 10.1093/nar/24.1.147.
2
p53 and APC gene mutations: software and databases.p53与APC基因突变：软件与数据库
Nucleic Acids Res. 1997 Jan 1;25(1):138. doi: 10.1093/nar/25.1.138.
3
p53 gene mutation: software and database.p53基因突变：软件与数据库
Nucleic Acids Res. 1998 Jan 1;26(1):200-4. doi: 10.1093/nar/26.1.200.
4
Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects.人类肿瘤和细胞系中p53基因体细胞突变数据库：最新汇编与未来展望
Nucleic Acids Res. 1997 Jan 1;25(1):151-7. doi: 10.1093/nar/25.1.151.
5
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools.国际癌症研究机构人类肿瘤和细胞系中p53基因突变数据库：更新汇编、修订格式及新的可视化工具
Nucleic Acids Res. 1998 Jan 1;26(1):205-13. doi: 10.1093/nar/26.1.205.
6
IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer.国际癌症研究机构p53突变数据库：用于汇编和分析人类肿瘤及细胞系中p53突变的关系型数据库。国际癌症研究机构。
Hum Mutat. 1999;14(1):1-8. doi: 10.1002/(SICI)1098-1004(1999)14:1<1::AID-HUMU1>3.0.CO;2-H.
7
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation.人类肿瘤和细胞系中p53基因的体细胞点突变：最新汇编。
Nucleic Acids Res. 1996 Jan 1;24(1):141-6. doi: 10.1093/nar/24.1.141.
8
Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses.旨在促进分子流行病学分析的p53和APC肿瘤抑制基因突变数据库。
Hum Mutat. 1996;7(3):202-13. doi: 10.1002/(SICI)1098-1004(1996)7:3<202::AID-HUMU4>3.0.CO;2-C.
9
Database of p53 gene somatic mutations in human tumors and cell lines.人类肿瘤和细胞系中p53基因体细胞突变数据库。
Nucleic Acids Res. 1994 Sep;22(17):3551-5.
10
p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis.p53网站与人类癌症中p53基因突变分析：建立流行病学与致癌作用之间的联系
Hum Mutat. 2000;15(1):105-13. doi: 10.1002/(SICI)1098-1004(200001)15:1<105::AID-HUMU19>3.0.CO;2-G.

引用本文的文献

1
The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.TP53 网站：TP53 突变数据库和 TP53 突变分析的综合资源中心。
Nucleic Acids Res. 2013 Jan;41(Database issue):D962-9. doi: 10.1093/nar/gks1033. Epub 2012 Nov 17.
2
p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis.胃癌中p53突变模式以及c-erbB2和c-met的表达：与组织学亚型、幽门螺杆菌感染及预后的关系
Dig Dis Sci. 2002 Jan;47(1):114-21. doi: 10.1023/a:1013275706401.
3
Translational control of human p53 expression in yeast mediated by 5'-UTR-ORF structural interaction.5'-UTR-ORF结构相互作用介导的酵母中人类p53表达的翻译调控。
Nucleic Acids Res. 2001 Mar 1;29(5):1222-7. doi: 10.1093/nar/29.5.1222.
4
p73 competes with p53 and attenuates its response in a human ovarian cancer cell line.p73在人卵巢癌细胞系中与p53竞争并减弱其反应。
Nucleic Acids Res. 2000 Jan 15;28(2):513-9. doi: 10.1093/nar/28.2.513.
5
MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas.血管肉瘤中MDM - 2癌蛋白过表达、p53基因突变及VEGF上调
Am J Pathol. 1998 Nov;153(5):1425-33. doi: 10.1016/S0002-9440(10)65729-X.
6
Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis.对苯二酚会导致特定突变，并引发细胞转化和体内肿瘤发生。
Br J Cancer. 1998 Aug;78(3):312-20. doi: 10.1038/bjc.1998.492.
7
p53 gene mutation and loss of heterozygosity of chromosome 11 in methylcholanthrene-induced mouse sarcomas.甲基胆蒽诱导的小鼠肉瘤中p53基因突变及11号染色体杂合性缺失
Jpn J Cancer Res. 1998 Mar;89(3):269-77. doi: 10.1111/j.1349-7006.1998.tb00558.x.
8
Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene.p53肿瘤抑制基因对滑膜细胞增殖、凋亡及侵袭的调控
Am J Pathol. 1998 Apr;152(4):1091-8.
9
Software and database for the analysis of mutations in the VHL gene.用于分析VHL基因突变的软件和数据库。
Nucleic Acids Res. 1998 Jan 1;26(1):256-8. doi: 10.1093/nar/26.1.256.
10
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools.国际癌症研究机构人类肿瘤和细胞系中p53基因突变数据库：更新汇编、修订格式及新的可视化工具
Nucleic Acids Res. 1998 Jan 1;26(1):205-13. doi: 10.1093/nar/26.1.205.

本文引用的文献

1
Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.在家族性腺瘤性息肉病患者中，眼底病变局限于腺瘤性息肉病 coli 基因特定亚组的 APC 突变。
Cell. 1993 Dec 3;75(5):959-68. doi: 10.1016/0092-8674(93)90539-3.
2
Alleles of the APC gene: an attenuated form of familial polyposis.APC基因的等位基因：家族性腺瘤性息肉病的一种弱化形式。
Cell. 1993 Dec 3;75(5):951-7. doi: 10.1016/0092-8674(93)90538-2.
3
p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis.
Oncogene. 1994 Oct;9(10):2869-75.
4
Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.对最具代表性的肿瘤来源的p53突变体进行分析后发现，蛋白质构象的变化与反式激活的丧失或细胞增殖的抑制并无关联。
EMBO J. 1994 Aug 1;13(15):3496-504. doi: 10.1002/j.1460-2075.1994.tb06656.x.
5
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.p53肿瘤抑制因子-DNA复合物的晶体结构：理解致癌突变
Science. 1994 Jul 15;265(5170):346-55. doi: 10.1126/science.8023157.
6
Sunburn and p53 in the onset of skin cancer.晒伤与p53在皮肤癌发病中的作用
Nature. 1994;372(6508):773-6. doi: 10.1038/372773a0.
7
Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes and Hirschsprung disease.
J Cell Sci Suppl. 1994;18:43-9. doi: 10.1242/jcs.1994.supplement_18.6.
8
Positional cloning moves from perditional to traditional.定位克隆从预测性转向传统性。
Nat Genet. 1995 Apr;9(4):347-50. doi: 10.1038/ng0495-347.
9
Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?我们能否通过分析p53基因的突变谱来预测太阳紫外线辐射是人类肿瘤中的致病因素？
Mutat Res. 1994 May 1;307(1):375-86. doi: 10.1016/0027-5107(94)90311-5.
10
Structural aspects of the p53 protein in relation to gene evolution.与基因进化相关的p53蛋白的结构方面
Oncogene. 1990 Jul;5(7):945-52.

p53基因突变：软件与数据库

p53 gene mutation: software and database.

作者信息

Béroud C, Verdier F, Soussi T

机构信息

Hôpital Necker Enfants Malades, U383 INSERM, Paris, France.

出版信息

Nucleic Acids Res. 1996 Jan 1;24(1):147-50. doi: 10.1093/nar/24.1.147.

DOI:10.1093/nar/24.1.147
PMID:8594565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC145567/
Abstract

A large number of different mutations in the tumor suppressor gene p53 gene have been identified in all types of cancer. As of September 1995, this database contains over 4200 mutations. This substantial increase since our previous report can enable epidemiological analyses which were not previously possible. In order to capture all these new data, the software permitting analysis has been improved. This report describes the various improvements since first release of the database.

摘要

在所有类型的癌症中，已发现肿瘤抑制基因p53基因存在大量不同的突变。截至1995年9月，该数据库包含超过4200个突变。自我们上次报告以来的大幅增加使得以前无法进行的流行病学分析成为可能。为了获取所有这些新数据，允许进行分析的软件已得到改进。本报告描述了自数据库首次发布以来的各种改进情况。