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傅里叶变换红外光谱法监测心肌梗死后细胞外基质的变化

Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy.

作者信息

Lui K, Jackson M, Sowa M G, Ju H, Dixon I M, Mantsch H H

机构信息

Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba.

出版信息

Biochim Biophys Acta. 1996 Mar 1;1315(2):73-7. doi: 10.1016/0925-4439(95)00118-2.

DOI:10.1016/0925-4439(95)00118-2
PMID:8608173
Abstract

Comparison of mid- and near-infrared spectra of control and infarcted rat ventricular tissue reveals the presence of absorptions in infarcted tissue which are highly characteristics of collagen, indicating large scale deposition of type I collagen in the myocardium following infarction. These results demonstrate that IR spectroscopy may be used to rapidly monitor the modifications of the extracellular matrix associated with myocardial infarction.

摘要

对照和梗死大鼠心室组织的中红外光谱与近红外光谱比较显示,梗死组织中存在具有高度胶原蛋白特征的吸收峰,表明梗死心肌中存在大量I型胶原蛋白沉积。这些结果表明,红外光谱可用于快速监测与心肌梗死相关的细胞外基质变化。

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