Muscat J E, Huncharek M
Division of Epidemiology, American Health Foundation, New York, NY, USA.
Br J Cancer. 1996 May;73(9):1122-5. doi: 10.1038/bjc.1996.215.
A high consumption of fruit and vegetables reduces the risk of several types of cancer. There is little information on the association between dietary intake and mesothelioma. A hospital-based case-control study of 94 men and women with malignant mesothelioma and 64 control patients without cancer was conducted to determine the odds associated with consumption of carotenoid-containing fruits and vegetables. After statistical adjustment for occupational asbestos exposure, the odds ratio was 0.2 [95% confidence interval (CI) 0.1-0.8] for carrot consumption and 0.5 (95% CI 0.2-1.4) for tomato consumption. However, the frequency of consuming other foods that have a high vitamin A or carotenoid content was not associated with a decreased risk of cancer. These results provide some justification for the hypothesis that provitamin A or beta-carotene may decrease the risk of mesothelioma. The body mass index was unrelated to the risk of mesothelioma.
大量食用水果和蔬菜可降低多种癌症的风险。关于饮食摄入与间皮瘤之间的关联，相关信息较少。开展了一项基于医院的病例对照研究，纳入94例患有恶性间皮瘤的男性和女性以及64例无癌症的对照患者，以确定食用含类胡萝卜素的水果和蔬菜的相关比值比。在对职业性石棉暴露进行统计调整后，食用胡萝卜的比值比为0.2[95%置信区间（CI）0.1 - 0.8]，食用番茄的比值比为0.5（95%CI 0.2 - 1.4）。然而，食用其他富含维生素A或类胡萝卜素食物的频率与癌症风险降低无关。这些结果为维生素A原或β-胡萝卜素可能降低间皮瘤风险这一假说提供了一定依据。体重指数与间皮瘤风险无关。
