Pollard M
Lobund Laboratory, University of Notre Dame, IN 4G556, USA.
Cancer Lett. 1997 Jan 1;111(1-2):221-4. doi: 10.1016/s0304-3835(96)04538-7.
The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swollen lymph nodes, compacted with PA-III cells, indicate that the 'normal' host-engendered level of intravascular non-specific restraints to metastasis were abrogated by CSA.
通过给予免疫抑制性环孢素A，前列腺腺癌III型细胞在Lobund-Wistar大鼠中的转移速率和转移程度有所增强。PA-III细胞从皮下PA-III衍生肿瘤扩散，通过同侧淋巴结，转移至肺部并在其中形成继发性肿瘤。充满PA-III细胞的肿大淋巴结表明，环孢素A消除了宿主产生的血管内对转移的“正常”非特异性抑制作用。
