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本文引用的文献

1
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.人单克隆抗体2G12可识别1型人类免疫缺陷病毒糖蛋白gp120上一个独特的中和表位。
J Virol. 1996 Feb;70(2):1100-8. doi: 10.1128/JVI.70.2.1100-1108.1996.
2
Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.人类免疫缺陷病毒1型gp120糖蛋白V1/V2区域氨基酸变化对亚基缔合、合胞体形成及中和抗体识别的影响。
J Virol. 1993 Jun;67(6):3674-9. doi: 10.1128/JVI.67.6.3674-3679.1993.
3
Secondary structure of gp160 and gp120 envelope glycoproteins of human immunodeficiency virus type 1: a Fourier transform infrared spectroscopic study.1型人类免疫缺陷病毒gp160和gp120包膜糖蛋白的二级结构：傅里叶变换红外光谱研究
J Virol. 1993 Jun;67(6):3552-60. doi: 10.1128/JVI.67.6.3552-3560.1993.
4
Synergistic inhibition of HIV-1 envelope-mediated cell fusion by CD4-based molecules in combination with antibodies to gp120 or gp41.基于CD4的分子与针对gp120或gp41的抗体联合对HIV-1包膜介导的细胞融合的协同抑制作用。
AIDS Res Hum Retroviruses. 1993 Jul;9(7):581-7. doi: 10.1089/aid.1993.9.581.
5
Evidence that the structural conformation of envelope gp120 affects human immunodeficiency virus type 1 infectivity, host range, and syncytium-forming ability.包膜糖蛋白gp120的结构构象影响人类免疫缺陷病毒1型感染性、宿主范围及形成合胞体能力的证据。
J Virol. 1993 Sep;67(9):5635-9. doi: 10.1128/JVI.67.9.5635-5639.1993.
6
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.1型人类免疫缺陷病毒包膜糖蛋白主要可变区缺失的功能和免疫学特征
J Virol. 1993 Aug;67(8):4557-65. doi: 10.1128/JVI.67.8.4557-4565.1993.
7
Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides.1型人类免疫缺陷病毒包膜糖蛋白被O-连接寡糖修饰。
J Virol. 1994 Jan;68(1):463-8. doi: 10.1128/JVI.68.1.463-468.1994.
8
Synergistic inhibition of HIV-1 by CD4 binding domain reagents and V3-directed monoclonal antibodies.CD4结合域试剂与V3导向单克隆抗体对HIV-1的协同抑制作用。
Virology. 1993 Nov;197(1):415-9. doi: 10.1006/viro.1993.1604.
9
Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.人类免疫缺陷病毒1型包膜糖蛋白gp120的V1/V2和C4结构域之间功能相互作用的证据。
J Virol. 1994 Apr;68(4):2503-12. doi: 10.1128/JVI.68.4.2503-2512.1994.
10
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.重组人单克隆抗体对HIV-1原始分离株的高效中和作用。
Science. 1994 Nov 11;266(5187):1024-7. doi: 10.1126/science.7973652.

人类免疫缺陷病毒1型gp120外膜糖蛋白的抗体交叉竞争分析

Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.

作者信息

Moore J P, Sodroski J

机构信息

Aaron Diamond AIDS Research Center, New York, New York 10016, USA.

出版信息

J Virol. 1996 Mar;70(3):1863-72. doi: 10.1128/JVI.70.3.1863-1872.1996.

DOI:10.1128/JVI.70.3.1863-1872.1996
PMID:8627711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190014/
Abstract

Forty-six monoclonal antibodies (MAbs) able to bind to the native, monomeric gp120 glycoprotein of the human immunodeficiency virus type 1 (HIV-1) LAI (HXBc2) strain were used to generate a competition matrix. The data suggest the existence of two faces of the gp120 glycoprotein. The binding sites for the viral receptor, CD4, and neutralizing MAbs appear to cluster on one face, which is presumably exposed on the assembled, oligomeric envelope glycoprotein complex. A second gp120 face, which is presumably inaccessible on the envelope glycoprotein complex, contains a number of epitopes for nonneutralizing antibodies. This analysis should be useful for understanding both the interaction of antibodies with the HIV-1 gp120 glycoprotein and neutralization of HIV-1.

摘要

46种能够与人免疫缺陷病毒1型（HIV-1）LAI（HXBc2）株天然单体gp120糖蛋白结合的单克隆抗体（MAb）被用于生成竞争矩阵。数据表明gp120糖蛋白存在两个面。病毒受体CD4和中和性单克隆抗体的结合位点似乎聚集在一个面上，这个面可能暴露在组装好的寡聚包膜糖蛋白复合物上。gp120的第二个面，可能在包膜糖蛋白复合物上无法接近，包含许多非中和性抗体的表位。该分析对于理解抗体与HIV-1 gp120糖蛋白的相互作用以及HIV-1的中和作用都应是有用的。