Quillen D A, Gass D M, Brod R D, Gardner T W, Blankenship G W, Gottlieb J L
Department of Ophthalmology, Penn State University, Hershey, Pennsylvania, USA.
Ophthalmology. 1996 Jan;103(1):72-9. doi: 10.1016/s0161-6420(96)30730-6.
Central serous chorioretinopathy is a disorder that typically affects young and middle-aged men. Although extensive information is available pertaining to the clinical features of central serous chorioretinopathy in men, little is known about this condition in women.
The authors reviewed the medical records and photographic files of women who received a diagnosis of central serous chorioretinopathy. The women were divided into three groups for data analysis: idiopathic, exogenous corticosteroid use, and pregnancy.
Fifty-one women with active central serous chorioretinopathy were evaluated. These findings in women with idiopathic serous chorioretinopathy were similar to those described in men, with the exception that women tend to be older at the time of onset. Central serous chorioretinopathy in women taking exogenous corticosteroids more likely was characterized by bilateral involvement and subretinal fibrin. Central serous chorioretinopathy in pregnant women typically developed in the third trimester and resolved spontaneously within 1-2 months after delivery.
Idiopathic central serous chorioretinopathy is similar in women and men, with the exception that women tend to be more older at the time of onset. The finding of exogenous corticosteroid use in a significant number of women in our study provides further support that cortisol may play a role in the development of central serous chorioretinopathy. The mechanism by which cortisol influences the development of central serous chorioretinopathy is unclear.
中心性浆液性脉络膜视网膜病变是一种通常影响中青年男性的疾病。尽管有大量关于男性中心性浆液性脉络膜视网膜病变临床特征的信息，但对于女性的这种疾病却知之甚少。
作者回顾了被诊断为中心性浆液性脉络膜视网膜病变的女性的病历和影像资料。这些女性被分为三组进行数据分析：特发性、外源性使用皮质类固醇和妊娠。
对51例活动性中心性浆液性脉络膜视网膜病变女性进行了评估。特发性浆液性脉络膜视网膜病变女性的这些表现与男性中描述的相似，不同之处在于女性发病时年龄往往更大。服用外源性皮质类固醇的女性中心性浆液性脉络膜视网膜病变更可能表现为双侧受累和视网膜下纤维蛋白。孕妇中心性浆液性脉络膜视网膜病变通常在妊娠晚期发病，并在产后1 - 2个月内自发消退。
特发性中心性浆液性脉络膜视网膜病变在女性和男性中相似，不同之处在于女性发病时年龄往往更大。我们研究中大量女性使用外源性皮质类固醇的发现进一步支持了皮质醇可能在中心性浆液性脉络膜视网膜病变的发生中起作用。皮质醇影响中心性浆液性脉络膜视网膜病变发生的机制尚不清楚。
