Hooymans J M
University Hospital of Groningen, Department of Ophthalmology, The Netherlands.
Graefes Arch Clin Exp Ophthalmol. 1998 Nov;236(11):876-9. doi: 10.1007/s004170050174.
The purpose of the study is to demonstrate the development of subretinal fibrotic scar formation in central serous chorioretinopathy (CSCR) that developed during systemic corticosteroid treatment.
The clinical and photographic records of a patient in whom an unusual manifestation of severe central serous chorioretinopathy developed during systemic corticosteroid treatment were reviewed.
A 34-year-old man received high dosages of corticosteroids for several years because of severe asthma. There was no previous history of idiopathic CSCR. He developed three successive attacks of CSCR. On the third occasion, an unusual variant of severe CSCR was observed which presented as a bullous sensory retinal detachment with subretinal serofibrinous exudate followed by subretinal fibrosis and fibrotic scar formation with contracting bands. After tapering of the corticosteroid dosage to a low level the retinal detachment resolved without laser treatment.
The finding suggests that during systemic corticosteroid treatment atypical manifestations of CSCR may develop with subretinal fibrosis and scar formation.
本研究的目的是证明在全身皮质类固醇治疗期间发生的中心性浆液性脉络膜视网膜病变（CSCR）中视网膜下纤维化瘢痕形成的发展情况。
回顾了一名患者的临床和照片记录，该患者在全身皮质类固醇治疗期间出现了严重中心性浆液性脉络膜视网膜病变的异常表现。
一名34岁男性因严重哮喘接受了数年高剂量皮质类固醇治疗。既往无特发性CSCR病史。他连续发生了三次CSCR发作。第三次发作时，观察到一种严重CSCR的异常变体，表现为大疱性感觉性视网膜脱离伴视网膜下浆液纤维蛋白渗出，随后出现视网膜下纤维化和纤维化瘢痕形成，并伴有收缩带。在将皮质类固醇剂量逐渐减至低水平后，视网膜脱离未经激光治疗即消退。
该发现表明，在全身皮质类固醇治疗期间，CSCR可能会出现伴有视网膜下纤维化和瘢痕形成的非典型表现。
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