Afut1，一种来自烟曲霉的类似反转录转座子的元件。
Afut1, a retrotransposon-like element from Aspergillus fumigatus.
作者信息
Neuveglise C, Sarfati J, Latge J P, Paris S
机构信息
Laboratoire des Aspergillus, Institut Pasteur, Paris, France.
出版信息
Nucleic Acids Res. 1996 Apr 15;24(8):1428-34. doi: 10.1093/nar/24.8.1428.
Abstract
A repeated DNA sequence used for epidemiological studies of the human opportunistic pathogen Aspergillus fumigatus has been characterized. It is a retroelement of 6914 bp in length, bounded by long terminal repeats of 282 bp, with sequence and features characteristic of retroviruses and retrotransposons. A 5 bp duplication site was found at its borders. This element, designated Afut1, encodes amino acid sequences homologous to the reverse transcriptase, RNase H and endonuclease encoded by the pol genes of retroelements. Comparison of the peptidic sequences with other putative polypeptides of fungal LTR retrotransposons showed that Afut1 is a member of the gypsy group. This is the first report of a transposable element in A.fumigatus. Afut1 is a defective element: the putative coding domains contain multiple stop codons due exclusively to transitions from C:G to T:A.
摘要
一种用于人类机会致病菌烟曲霉流行病学研究的重复DNA序列已得到表征。它是一个长度为6914 bp的反转录元件，由282 bp的长末端重复序列界定，具有逆转录病毒和反转录转座子的序列及特征。在其边界发现了一个5 bp的重复位点。该元件命名为Afut1，编码与反转录元件pol基因所编码的逆转录酶、核糖核酸酶H和内切核酸酶同源的氨基酸序列。将肽序列与真菌LTR反转录转座子的其他推定多肽进行比较表明，Afut1是吉普赛族的成员。这是关于烟曲霉中可转座元件的首次报道。Afut1是一个缺陷元件：推定的编码结构域仅由于从C:G到T:A的转换而包含多个终止密码子。
相似文献
1
Afut1, a retrotransposon-like element from Aspergillus fumigatus.Afut1，一种来自烟曲霉的类似反转录转座子的元件。
Nucleic Acids Res. 1996 Apr 15;24(8):1428-34. doi: 10.1093/nar/24.8.1428.
2
DAB1: a degenerate retrotransposon-like element from Neurospora crassa.DAB1：一种来自粗糙脉孢菌的类似简并反转录转座子的元件。
Mol Gen Genet. 1998 May;258(4):431-6. doi: 10.1007/s004380050752.
3
Afut2, a new family of degenerate gypsy-like retrotransposon from Aspergillus fumigatus.Afut2，烟曲霉中一个新的类似简并性吉普赛族反转录转座子家族。
Med Mycol. 2001 Apr;39(2):195-8. doi: 10.1080/mmy.39.2.195.198.
4
Prt1, an unusual retrotransposon-like sequence in the fungus Phycomyces blakesleeanus.Prt1，一种存在于布氏毛霉中的不寻常的类反转录转座子序列。
Mol Gen Genet. 1996 Dec 13;253(3):324-33. doi: 10.1007/pl00008599.
5
CfT-I: an LTR-retrotransposon in Cladosporium fulvum, a fungal pathogen of tomato.CfT-I：番茄叶霉病菌（一种番茄真菌病原体）中的一个长末端重复序列逆转座子。
Mol Gen Genet. 1992 Jun;233(3):337-47. doi: 10.1007/BF00265429.
6
Grasshopper, a long terminal repeat (LTR) retroelement in the phytopathogenic fungus Magnaporthe grisea.蚱蜢，一种存在于植物病原真菌稻瘟病菌中的长末端重复序列（LTR）反转录转座子。
Mol Plant Microbe Interact. 1993 Jan-Feb;6(1):114-26. doi: 10.1094/mpmi-6-114.
7
Structural features of mag, a gypsy-like retrotransposon of Bombyx mori, with unusual short terminal repeats.家蚕类吉普赛逆转录转座子mag的结构特征，具有异常短的末端重复序列。
Genetica. 1994;93(1-3):125-37. doi: 10.1007/BF01435245.
8
Skippy, a retrotransposon from the fungal plant pathogen Fusarium oxysporum.Skippy，一种来自真菌植物病原体尖孢镰刀菌的逆转座子。
Mol Gen Genet. 1995 Dec 20;249(6):637-47. doi: 10.1007/BF00418033.
9
A retrotransposon family from the pufferfish (fugu) Fugu rubripes.一种来自河豚（红鳍东方鲀）的反转录转座子家族。
Gene. 1998 Jul 30;215(2):241-9. doi: 10.1016/s0378-1119(98)00296-0.
10
Potential retroviruses in plants: Tat1 is related to a group of Arabidopsis thaliana Ty3/gypsy retrotransposons that encode envelope-like proteins.植物中的潜在逆转录病毒：Tat1与一组编码类包膜蛋白的拟南芥Ty3/gypsy逆转座子相关。
Genetics. 1998 Jun;149(2):703-15. doi: 10.1093/genetics/149.2.703.
引用本文的文献
1
Ty retrotransposon element based multiple integration toolkit for .基于Ty反转录转座子元件的多重整合工具包，用于…… （原文结尾不完整，翻译只能至此）
Synth Syst Biotechnol. 2025 Apr 23;10(3):887-896. doi: 10.1016/j.synbio.2025.04.011. eCollection 2025 Sep.
2
Examination of Genome-Wide Ortholog Variation in Clinical and Environmental Isolates of the Fungal Pathogen Aspergillus fumigatus.检测真菌病原体烟曲霉临床和环境分离株中全基因组直系同源变异。
mBio. 2022 Aug 30;13(4):e0151922. doi: 10.1128/mbio.01519-22. Epub 2022 Jun 29.
3
Genomic Variations and Mutational Events Associated with Plant-Pathogen Interactions.与植物-病原体相互作用相关的基因组变异和突变事件。
Biology (Basel). 2022 Mar 10;11(3):421. doi: 10.3390/biology11030421.
4
Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus.染色质分析揭示了人类病原体烟曲霉临床分离株的异质性。
PLoS Genet. 2022 Jan 10;18(1):e1010001. doi: 10.1371/journal.pgen.1010001. eCollection 2022 Jan.
5
Long Terminal Repeat Retrotransposon Promotes Azole Resistance of Aspergillus fumigatus by Enhancing the Expression of Gene.长末端重复逆转录转座子通过增强基因的表达促进烟曲霉对唑类药物的耐药性。
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0029121. doi: 10.1128/AAC.00291-21. Epub 2021 Sep 13.
6
and aspergillosis: From basics to clinics.以及曲霉病：从基础到临床
Stud Mycol. 2021 May 10;100:100115. doi: 10.1016/j.simyco.2021.100115. eCollection 2021 Sep.
7
Identification of CSP Types and Genotypic Variability of Clinical and Environmental Isolates of from Different Geographic Origins.不同地理来源的临床和环境分离株中CSP类型的鉴定及基因变异
Microorganisms. 2020 May 8;8(5):688. doi: 10.3390/microorganisms8050688.
8
Biocontrol strain Aspergillus flavus WRRL 1519 has differences in chromosomal organization and an increased number of transposon-like elements compared to other strains.生防菌黄曲霉 WRRL1519 与其他菌株相比，在染色体组织上存在差异，并且转座子样元件数量增加。
Mol Genet Genomics. 2018 Dec;293(6):1507-1522. doi: 10.1007/s00438-018-1474-x. Epub 2018 Aug 11.
9
Comparison of Two Highly Discriminatory Typing Methods to Analyze Azole Resistance.两种高分辨率分型方法用于分析唑类耐药性的比较
Front Microbiol. 2018 Jul 20;9:1626. doi: 10.3389/fmicb.2018.01626. eCollection 2018.
10
rRNA Pseudogenes in Filamentous Ascomycetes as Revealed by Genome Data.基因组数据揭示丝状子囊菌中的rRNA假基因
G3 (Bethesda). 2017 Aug 7;7(8):2695-2703. doi: 10.1534/g3.117.044016.
本文引用的文献
1
Characterization and partial nucleotide sequence of the DNA fingerprinting probe Ca3 of Candida albicans.白色念珠菌DNA指纹图谱探针Ca3的特性及部分核苷酸序列
J Clin Microbiol. 1993 Jun;31(6):1472-80. doi: 10.1128/jcm.31.6.1472-1480.1993.
2
Molecular epidemiology of nosocomial invasive aspergillosis.医院获得性侵袭性曲霉病的分子流行病学
J Clin Microbiol. 1994 Mar;32(3):684-90. doi: 10.1128/jcm.32.3.684-690.1994.
3
Ylt1, a highly repetitive retrotransposon in the genome of the dimorphic fungus Yarrowia lipolytica.Ylt1，一种在二型真菌解脂耶氏酵母基因组中高度重复的逆转录转座子。
J Bacteriol. 1994 May;176(9):2477-82. doi: 10.1128/jb.176.9.2477-2482.1994.
4
Use of DNA moderately repetitive sequence to type Aspergillus fumigatus isolates from aspergilloma patients.使用DNA中度重复序列对曲菌球患者的烟曲霉分离株进行分型。
J Infect Dis. 1994 Mar;169(3):683-5. doi: 10.1093/infdis/169.3.683.
5
Development of DNA probes for fingerprinting Aspergillus fumigatus.用于烟曲霉指纹图谱分析的DNA探针的开发。
J Clin Microbiol. 1993 Jun;31(6):1547-54. doi: 10.1128/jcm.31.6.1547-1554.1993.
6
Boty, a long-terminal-repeat retroelement in the phytopathogenic fungus Botrytis cinerea.博蒂，一种存在于植物致病真菌灰葡萄孢中的长末端重复逆转座子。
Appl Environ Microbiol. 1995 Jan;61(1):103-8. doi: 10.1128/aem.61.1.103-108.1995.
7
Molecular characterization of the food-borne fungus Neosartorya fischeri (Malloch and Cain).食源性真菌费氏新萨托菌（马洛赫和凯恩）的分子特征分析
Appl Environ Microbiol. 1995 Apr;61(4):1378-83. doi: 10.1128/aem.61.4.1378-1383.1995.
8
Gypsy/Ty3-class retrotransposons integrated in the DNA of herring, tunicate, and echinoderms.吉普赛/Ty3类逆转座子整合在鲱鱼、被囊动物和棘皮动物的DNA中。
J Mol Evol. 1995 Jan;40(1):13-24. doi: 10.1007/BF00166592.
9
Grasshopper, a long terminal repeat (LTR) retroelement in the phytopathogenic fungus Magnaporthe grisea.蚱蜢，一种存在于植物病原真菌稻瘟病菌中的长末端重复序列（LTR）反转录转座子。
Mol Plant Microbe Interact. 1993 Jan-Feb;6(1):114-26. doi: 10.1094/mpmi-6-114.
10
Evidence for nosocomial transmission of Candida albicans obtained by Ca3 fingerprinting.通过Ca3指纹图谱获得的白色念珠菌医院内传播的证据。
J Clin Microbiol. 1995 May;33(5):1223-30. doi: 10.1128/jcm.33.5.1223-1230.1995.
Zotero 插件