Freudenberg J, Baumann H, Arnold W, Berger J, Büschenfelde K H
Digestion. 1977;15(4):260-70. doi: 10.1159/000198011.
108 adult patients and 34 children with chronic active hepatitis (CAH) are divided in four groups on the basis of presence and absence of hepatitis B surface antigen (HBsAg) and autoantibodies (AutoAb). There are significant differences in the numeric distribution among the four groups and the sex distribution between adult patients and children, but no differences in the frequencies of the HLA antigens tested. An increased frequency of HLA-B8 (and HLA-A1) compared with normal controls and the other groups is only found in autoimmune types of CAH, characterized as HBsAg-negative, AutoAb-positive CAH. HBsAg-negative, AutoAb-negative forms of CAH are called cyptogenic CAH and these are most likely non-hepatitis B virus induced types of CAH. In these and hepatitis B virus induced forms of CAH no significant deviation of any HLA antigen tested could be found.
108例成年患者和34例慢性活动性肝炎（CAH）患儿根据乙肝表面抗原（HBsAg）和自身抗体（AutoAb）的有无分为四组。四组之间的数值分布以及成年患者与儿童之间的性别分布存在显著差异，但所检测的HLA抗原频率无差异。与正常对照组及其他组相比，仅在自身免疫型CAH（其特征为HBsAg阴性、AutoAb阳性CAH）中发现HLA - B8（和HLA - A1）频率增加。HBsAg阴性、AutoAb阴性的CAH形式称为隐源性CAH，这些很可能是非乙肝病毒诱导的CAH类型。在这些以及乙肝病毒诱导的CAH形式中，未发现所检测的任何HLA抗原存在显著偏差。
