Mazzilli M C, Trabace S, Raimondo F D, Gandini E, Visco G
Digestion. 1977;15(4):278-85. doi: 10.1159/000198013.
42 patients (33 males and 9 females) with chromic active hepatitis (CAH) mostly HBsAg+, were typed for 24 alleles of the A and B loci. Diagnosis was performed according to the criteria outlined by the European Association for the Study of the Liver. The increased frequency of HLA-A3 (47.6% instead of 19.1% in 266 healthy controls) is significant after correction. The relative risk is 3.83. The phenotypic association A3/Bw35 is also increased (28.5% instead of 6.0 in the control group). The risk of the A3/Bw35 association is 6.25. The risk of A3 calculated in patients lacking Bw35 is 1.6. A family study in 5 patients over 5 showed an haplotype A3/Bw35.
42例慢性活动性肝炎（CAH）患者（33例男性，9例女性），多数为HBsAg阳性，对A和B位点的24个等位基因进行分型。诊断依据欧洲肝脏研究协会制定的标准进行。校正后，HLA - A3频率增加（47.6%，而266名健康对照者中为19.1%）具有显著性。相对风险为3.83。A3/Bw35的表型关联也增加（28.5%，而对照组为6.0）。A3/Bw35关联的风险为6.25。在缺乏Bw35的患者中计算出的A3风险为1.6。对5例以上患者的家系研究显示存在单倍型A3/Bw35。
