Rabinovitz M, Demetris A J, Bou-Abboud C F, Van Thiel D H
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Dig Dis Sci. 1992 Oct;37(10):1606-11. doi: 10.1007/BF01296509.
The simultaneous occurrence of PSC and autoimmune CAH in a patient with ulcerative colitis is described. Although each disease is a well documented complication of UC, their combination has never been reported. The diagnosis of PSC was based on typical findings on ERCP and liver biopsy and that of CAH was based on typical findings on liver biopsy supported by HLA typings and a remarkable response to a combination of glucocorticoids and azathioprine. The difficulties in establishing the diagnosis and the management of such patients are discussed.
本文描述了一名溃疡性结肠炎患者同时发生原发性硬化性胆管炎（PSC）和自身免疫性慢性活动性肝炎（CAH）的情况。尽管每种疾病都是溃疡性结肠炎（UC）的一种有充分文献记载的并发症，但它们的合并情况从未被报道过。PSC的诊断基于内镜逆行胰胆管造影（ERCP）和肝脏活检的典型表现，CAH的诊断基于肝脏活检的典型表现，并得到人类白细胞抗原（HLA）分型的支持，以及对糖皮质激素和硫唑嘌呤联合治疗的显著反应。文中还讨论了诊断此类患者的困难及管理方法。
