440例血液透析患者的HLA - A1、B8表型关联与乙肝表面抗原血症演变
HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients.
作者信息
Descamps B, Jungers P, Naret C, Degott C, Zingraff J, Bach J F
出版信息
Digestion. 1977;15(4):271-7. doi: 10.1159/000198012.
HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HL-A-A1, B8 association (18.6%) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05%, p less than 10(-4), and with the group of patients unable to eliminate HBsAg (7.0%, less than 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.
对440例血液透析患者每月随访乙肝表面抗原（HBsAg），并对A和B位点的26个HLA等位基因进行分型。与正常法国人群（5.05%，p<10⁻⁴）以及无法清除HBsAg的患者组（7.0%，p<0.01）相比，能够清除HBsAg的患者组中HL - A - A1、B8关联率异常高（18.6%）。慢性侵袭性肝炎仅在后者中发现。在血清阴性的活动性慢性肝炎患者中也发现了HLA - A1、B8关联的高频率，这表明该表型可能与针对HBsAg的高免疫反应有关。
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