Raymond J L, Lisberger S G, Mauk M D
Department of Physiology, University of California, San Francisco, 94143, USA.
Science. 1996 May 24;272(5265):1126-31. doi: 10.1126/science.272.5265.1126.
Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibulo-ocular reflex suggests that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a special role in learning the timing of movement; and (iii) the cerebellar cortex guides learning in the deep nuclei, which may allow learning to be transferred from the cortex to the deep nuclei. Because many of the similarities in the data from the two systems typify general features of cerebellar organization, the cerebellar mechanisms of learning in these two systems may represent principles that apply to many motor systems.
对两种看似截然不同的行为进行比较，得出了关于小脑在运动学习中作用的惊人一致的图景。有关眼睑反应经典条件反射和前庭眼反射中运动学习的行为和生理数据表明：（i）可塑性分布在小脑皮质和小脑深部核团之间；（ii）小脑皮质在学习运动时间方面起特殊作用；（iii）小脑皮质引导深部核团的学习，这可能使学习能够从小脑皮质转移到深部核团。由于来自这两个系统的数据中的许多相似之处代表了小脑组织的一般特征，因此这两个系统中学习的小脑机制可能代表了适用于许多运动系统的原则。
