微小菌素J25产生及免疫的质粒决定因素的遗传分析。
Genetic analysis of plasmid determinants for microcin J25 production and immunity.
作者信息
Solbiati J O, Ciaccio M, Farías R N, Salomón R A
机构信息
Departamento de Bioquímica de la Nutrición, Instituto Superior de Investigaciones Biológicas, Tucumán, Argentina.
出版信息
J Bacteriol. 1996 Jun;178(12):3661-3. doi: 10.1128/jb.178.12.3661-3663.1996.
Abstract
Microcin J25 (MccJ25) is a small peptide antibiotic produced by an Escherichia coli strain isolated from human feces. The genetic determinants for MccJ25 synthesis and immunity have been cloned from the low-copy-number wild-type plasmid pTUC1OO into the compatible vectors pBR322 and pACYC184. Physical and phenotypical analysis of insertion mutations and complementation tests defined three contiguous genes involved in MccJ25 production which span a region of about 2.2 kb. Immunity to the antibiotic is provided by an additional gene adjacent to the production region.
摘要
微菌素J25（MccJ25）是一种由从人类粪便中分离出的大肠杆菌菌株产生的小肽抗生素。MccJ25合成和免疫的遗传决定因素已从低拷贝数野生型质粒pTUC100克隆到相容载体pBR322和pACYC184中。插入突变的物理和表型分析以及互补试验确定了参与MccJ25产生的三个相邻基因，它们跨越约2.2 kb的区域。抗生素免疫由生产区域附近的另一个基因提供。
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