分离细胞核中RNA加工的原黄素敏感性。
Proflavine sensitivity of RNA processing in isolated nuclei.
作者信息
Yannarell A, Niemann M, Schumm D E, Webb T E
出版信息
Nucleic Acids Res. 1977 Mar;4(3):503-11. doi: 10.1093/nar/4.3.503.
Abstract
The intercalating agent proflavine inhibits the processing and subsequent release of preformed messenger RNA and ribosomal RNA from isolated liver nuclei to surrogate cytoplasm. The direct effect of proflavine on these processes, as monitored in a reconstituted cell-free system, supports the theory that base-paired segments (i.e. hairpin loops) in the precursor RNA's are involved as recognition sites in nuclear RNA processing.
摘要
嵌入剂原黄素可抑制从分离的肝细胞核到替代细胞质的预制信使核糖核酸和核糖体核糖核酸的加工及随后的释放。在重构的无细胞系统中监测到的原黄素对这些过程的直接作用，支持了前体核糖核酸中的碱基配对片段（即发夹环）作为核核糖核酸加工中的识别位点的理论。
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