Bendig J W, Fleming D M
Epsom Public Health Laboratory, Royal College of General Practitioners Research Unit, Birmingham.
Commun Dis Rep CDR Rev. 1996 May 24;6(6):R81-6.
We describe the epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease, attributed to coxsackie A virus serotype 16, that occurred throughout England and Wales in the last quarter of 1994. Nine hundred and fifty-two cases were reported by spotter practices that make weekly returns to the Royal College of General Practitioners, which made this the largest epidemic of hand, foot, and mouth disease in England and Wales reported to date. Most patients were aged 1 to 4 years and lived in central or southern regions. Clinical features were unavailable from the weekly returns but were described in detail for 39 patients, mostly by means of a questionnaire to general practitioners near the PHLS Coxsackie Reference Laboratory. All cases had a rash on their hands and 23 also had rashes on their feet and in their mouths. Most cases were mild. Severity was associated with the degree of mouth involvement. Secondary cases in family members were rare. Data from the Royal College of General Practitioners since 1963 reveal a period between epidemics of two to three years. The epidemics in 1988 and 1990 also occurred in the last quarters of these years and cases were concentrated in the central and southern regions.
我们描述了1994年最后一个季度在英格兰和威尔士发生的由16型柯萨奇A病毒引起的手足口病疫情的流行病学、病毒学和临床特征。向皇家全科医师学院每周汇报情况的监测医疗机构报告了952例病例，这是英格兰和威尔士迄今为止报告的最大规模的手足口病疫情。大多数患者年龄在1至4岁，居住在中部或南部地区。每周汇报中没有提供临床特征，但对39例患者进行了详细描述，主要是通过向公共卫生实验室服务中心柯萨奇参考实验室附近的全科医生发放调查问卷的方式。所有病例手上都有皮疹，23例脚上和口腔也有皮疹。大多数病例症状轻微。严重程度与口腔受累程度有关。家庭成员中的二代病例很少见。自1963年以来皇家全科医师学院的数据显示，疫情之间的间隔期为两到三年。1988年和1990年的疫情也发生在这两年的最后一个季度，病例集中在中部和南部地区。
