一类树突状细胞通过Fas/ Fas配体诱导的凋亡杀死CD4 T细胞。
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.
作者信息
Süss G, Shortman K
机构信息
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
出版信息
J Exp Med. 1996 Apr 1;183(4):1789-96. doi: 10.1084/jem.183.4.1789.
Abstract
Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.
摘要
树突状细胞（DC）是最有效的抗原呈递细胞，通过高水平表达主要组织相容性复合体和共刺激分子，它们具备激活初始CD4+ T细胞的良好条件。我们现在证明，一些DC同样具备杀死这些相同T细胞的能力。小鼠脾DC由传统的CD8α- DC和主要的CD8α+ DC群体组成。虽然CD8- DC在CD4 T细胞中诱导强烈的增殖反应，但CD8+ DC诱导的反应较弱，且与明显的T细胞凋亡相关。通过使用来自Fas突变的lpr/lpr小鼠和Fas配体（FasL）突变的gld/gld小鼠的各种T细胞和DC混合物，我们表明这种死亡是由于活化T细胞上的Fas与CD8+ DC上的FasL相互作用所致。此外，我们通过直接表面染色表明，CD8+ DC而非CD8- DC高水平表达FasL。这些发现表明，FasL+ CD8+ DC是DC的一个特殊亚群，在调节外周初始T细胞反应中发挥作用。
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