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本文引用的文献

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Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.自身免疫性lpr/lpr小鼠的成熟T细胞在抗原刺激下的自杀过程中存在缺陷。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4409-13. doi: 10.1073/pnas.90.10.4409.
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Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population.胸腺树突状细胞和T细胞在胸腺中由共同的前体细胞群同时发育而来。
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Antigen-presenting cell types.抗原呈递细胞类型。
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Simultaneous determination of cell surface antigens and apoptosis.细胞表面抗原与细胞凋亡的同步检测
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A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice.在自身免疫性lpr和gld小鼠的成熟外周T细胞中，凋亡性细胞死亡的一种特定细胞间途径存在缺陷。
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Regulation of apoptosis in the immune system.免疫系统中细胞凋亡的调控。
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Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.具有II类主要组织相容性复合体限制性受体的CD8 +单阳性细胞的胸腺选择。
J Exp Med. 1994 Jul 1;180(1):25-34. doi: 10.1084/jem.180.1.25.
8
The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster.小鼠Fas配体基因在gld小鼠中发生突变，是肿瘤坏死因子（TNF）家族基因簇的一部分。
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Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation.小鼠胸腺树突状细胞：发育动力学及成熟过程中表面标志物的变化
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A role for CD95 ligand in preventing graft rejection.CD95配体在预防移植排斥反应中的作用。
Nature. 1995 Oct 19;377(6550):630-2. doi: 10.1038/377630a0.

一类树突状细胞通过Fas/ Fas配体诱导的凋亡杀死CD4 T细胞。

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

作者信息

Süss G, Shortman K

机构信息

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

出版信息

J Exp Med. 1996 Apr 1;183(4):1789-96. doi: 10.1084/jem.183.4.1789.

DOI:10.1084/jem.183.4.1789
PMID:8666935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192509/
Abstract

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.

摘要

树突状细胞（DC）是最有效的抗原呈递细胞，通过高水平表达主要组织相容性复合体和共刺激分子，它们具备激活初始CD4+ T细胞的良好条件。我们现在证明，一些DC同样具备杀死这些相同T细胞的能力。小鼠脾DC由传统的CD8α- DC和主要的CD8α+ DC群体组成。虽然CD8- DC在CD4 T细胞中诱导强烈的增殖反应，但CD8+ DC诱导的反应较弱，且与明显的T细胞凋亡相关。通过使用来自Fas突变的lpr/lpr小鼠和Fas配体（FasL）突变的gld/gld小鼠的各种T细胞和DC混合物，我们表明这种死亡是由于活化T细胞上的Fas与CD8+ DC上的FasL相互作用所致。此外，我们通过直接表面染色表明，CD8+ DC而非CD8- DC高水平表达FasL。这些发现表明，FasL+ CD8+ DC是DC的一个特殊亚群，在调节外周初始T细胞反应中发挥作用。