脑膜脑炎中的脑脊液可溶性L-选择素（sCD62L）
Cerebrospinal fluid soluble L-selectin (sCD62L) in meningoencephalitis.
作者信息
Bührer C, Herold R, Stibenz D, Henze G, Obladen M
机构信息
Department of Neonatology, Children's Hospital, Humboldt University, Berlin, Germany.
出版信息
Arch Dis Child. 1996 Apr;74(4):288-92. doi: 10.1136/adc.74.4.288.
The leucocyte adhesion molecule L-selectin (CD62L) is rapidly cleaved off proteolytically after cell activation, generating soluble L-selectin (sCD62L) molecules. sCD62L concentrations were determined in 185 cerebrospinal fluid (CSF) samples obtained from children aged 1 month to 17 years. In 36 CSF samples of children with meningoencephalitis, sCD62L was significantly higher (median 209 fmol/ml) than in samples of children with other febrile diseases (n = 67, median 50 fmol/ml) or non-febrile disorders (n = 82, median 44 fmol/ml). There was a positive correlation between CSF protein and CSF sCD62L (rS = 0.68), suggesting that a disturbed blood-brain barrier contributes to raised sCD62L concentrations in the CSF. However, the CSF sCD62L/protein ratio of children with meningoencephalitis was significantly higher than in children with other febrile diseases or non-febrile disorders, indicating that sCD62L concentrations in children with meningoencephalitis were higher than expected from plasma leakage alone. It is concluded that both an impaired blood-brain barrier and the generation of sCD62L by infiltrating leucocytes contribute to raised CSF sCD62L concentrations in children with meningoencephalitis.
白细胞粘附分子L-选择素（CD62L）在细胞活化后会迅速被蛋白水解切割，产生可溶性L-选择素（sCD62L）分子。对185份来自1个月至17岁儿童的脑脊液（CSF）样本测定了sCD62L浓度。在36份患脑膜脑炎儿童的脑脊液样本中，sCD62L显著高于其他发热性疾病儿童的样本（n = 67，中位数为50 fmol/ml）或非发热性疾病儿童的样本（n = 82，中位数为44 fmol/ml）。脑脊液蛋白与脑脊液sCD62L之间存在正相关（rS = 0.68），这表明血脑屏障受损导致脑脊液中sCD62L浓度升高。然而，脑膜脑炎儿童的脑脊液sCD62L/蛋白比值显著高于其他发热性疾病或非发热性疾病儿童，这表明脑膜脑炎儿童的sCD62L浓度高于仅由血浆渗漏所预期的浓度。得出的结论是，血脑屏障受损和浸润白细胞产生sCD62L均导致脑膜脑炎儿童脑脊液中sCD62L浓度升高。
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