Koransky J R, Jacobs N F
Sex Transm Dis. 1977 Jan-Mar;4(1):27-31. doi: 10.1097/00007435-197701000-00009.
A simple, adequately evaluated serologic test is not now available for use in gonorrhea screening programs. Some of the factors responsible for the relatively low sensitivity and specificity of serologic tests for gonorrhea as compared to cultural techniques are discussed. These include the time required for development of an immunologic response after infection, cross-reactivity with other antigens, and the persistence of antibody after therapy. At present, gonococcal serologic tests may be useful to the clinician in establishing the diagnosis of disseminated gonococcal infection, especially if paired sera demonstrate a change in antibody titer. Current research on the antigenic structure of the gonococcus may lead to the development of improved serologic tests for use in screening programs. However, the performance of any test may vary according to sex of the patient, presence of symptoms, history of prior gonococcal infection, and duration of the current infection. The physician must understand these factors when considering the use of any serologic test for gonorrhea.
目前尚无一种简单且经过充分评估的血清学检测方法可用于淋病筛查项目。本文讨论了与培养技术相比，淋病血清学检测灵敏度和特异性相对较低的一些原因。这些因素包括感染后产生免疫反应所需的时间、与其他抗原的交叉反应以及治疗后抗体的持续存在。目前，淋球菌血清学检测可能有助于临床医生诊断播散性淋球菌感染，特别是如果双份血清显示抗体滴度有变化时。目前对淋球菌抗原结构的研究可能会促使开发出更适合用于筛查项目的血清学检测方法。然而，任何检测方法的性能可能会因患者性别、症状的有无、既往淋球菌感染史以及当前感染持续时间而有所不同。医生在考虑使用任何淋病血清学检测方法时必须了解这些因素。
