Krabbe S, Skakkebaek N E, Berthelsen J G, Eyben F V, Volsted P, Mauritzen K, Eldrup J, Nielsen A H
Lancet. 1979 May 12;1(8124):999-1000. doi: 10.1016/s0140-6736(79)92754-5.
Testicular biopsy specimens from 4 (8%) of 50 men previously treated for maldescended testes had a carcinoma-in-situ pattern. 2 of these men had adjacent invasive carcinoma (seminoma and embryonal carcinoma). The patient with embryonal carcinoma had an enlarged testis but the 3 other patients with neoplasia had no clinical signs or symptoms of malignancy. Routine follow-up including testicular biopsy in young men with maldescended testes is essential because of the increased risk of malignancy and may detect testicular neoplasia at a stage when orchidectomy alone is curative.
50名曾接受隐睾治疗的男性中，有4名（8%）的睾丸活检标本呈现原位癌模式。其中2名男性伴有相邻的浸润性癌（精原细胞瘤和胚胎癌）。患有胚胎癌的患者睾丸增大，但其他3名患有肿瘤的患者没有恶性肿瘤的临床体征或症状。由于恶性肿瘤风险增加，对患有隐睾的年轻男性进行包括睾丸活检在内的常规随访至关重要，且可能在仅行睾丸切除术即可治愈的阶段检测出睾丸肿瘤。
